S'abonner

Association between adjuvant posterior repair and success of native tissue apical suspension - 28/01/20

Doi : 10.1016/j.ajog.2019.08.024 
Gary Sutkin, MD a, , Halina M. Zyczynski, MD b, Amaanti Sridhar, MD c, J. Eric Jelovsek, MD, MMEd d, Charles R. Rardin, MD e, Donna Mazloomdoost, MD f, David D. Rahn, MD g, John N. Nguyen, MD h, Uduak U. Andy, MD i, Isuzu Meyer, MD j, Marie G. Gantz, PhD c
for the

NICHD Pelvic Floor Disorders Network

a Department of Obstetrics and Gynecology, University of Missouri Kansas City, Kansas City, MO 
b Division Urogynecology and Reconstructive Pelvic Surgery, Magee-Womens Research Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA 
c RTI International, Research Triangle Park, NC 
d Duke University, Durham, NC 
e Divison of Urogyneology, Alpert Medical School of Brown University, Providence, RI 
f NICHD/NIH, Rockville, MD 
g Division of Female Pelvic Medicine and Reconstructive Surgery, UT Southwestern, Dallas, TX 
h Department of Obstetrics and Gynecology, Southern California Permanente Medical Group, Downey, CA 
i Department of Obstetrics and Gynecology, Hospital of the University of Pennsylvania, Philadelphia, PA 
j Division of Urogynecology and Pelvic Reconstructive Surgery, University of Alabama at Birmingham, Birmingham, AL 

Corresponding author: Gary Sutkin, MD.

Abstract

Background

Posterior repairs and perineorrhaphies are often performed in prolapse surgery to reduce the size of the genital hiatus. The benefit of an adjuvant posterior repair at the time of sacrospinous ligament fixation or uterosacral ligament suspension is unknown.

Objective

We aimed to determine whether an adjuvant posterior repair at transvaginal apical suspension is associated with improved surgical success.

Materials and Methods

This secondary analysis of Operations and Pelvic Muscle Training in the Management of Apical Support Loss (OPTIMAL) trial compared 24-month outcomes in 190 participants who had a posterior repair (posterior repair group) and 184 who did not (no posterior repair group) at the time of sacrospinous ligament fixation or uterosacral ligament suspension. Concomitant posterior repair was performed at the surgeon’s discretion. Primary composite outcome of “surgical success” was defined as no prolapse beyond the hymen, point C ≤ –2/3 total vaginal length, no bothersome bulge symptoms, and no retreatment at 24 months. The individual components were secondary outcomes. Propensity score methods were used to build models that balanced posterior repair group and the no posterior repair group for ethnographic factors and preoperative Pelvic Organ Prolapse Quantification values. Adjusted odds ratios were calculated to predict surgical success based on the performance of a posterior repair. Groups were also compared with unadjusted χ2 analyses. An unadjusted probability curve was created for surgical success as predicted by preoperative genital hiatus.

Results

Women in the posterior repair group were less likely to be Hispanic or Latina, and were more likely to have had a prior hysterectomy and to be on estrogen therapy. The groups did not differ with respect to preoperative Pelvic Organ Prolapse Quantification stage; however, subjects in the posterior repair group had significantly greater preoperative posterior wall prolapse. There were no group differences in surgical success using propensity score methods (66.7% posterior repair vs 62.0% no posterior repair; adjusted odds ratio, 1.07; 95% confidence interval, 0.56–2.07; P = 0.83) or unadjusted test (66.2% posterior repair vs 61.7% no posterior repair; P = 0.47). Individual outcome measures of prolapse recurrence (bothersome bulge symptoms, prolapse beyond the hymen, or retreatment for prolapse) also did not differ by group. Similarly, there were no differences between groups in anatomic outcomes of any individual compartment (anterior, apical, or posterior) at 24 months. There was high variation in performance of posterior repair by surgeon (interquartile range, 15–79%). The unadjusted probability of overall success at 24 months, regardless of posterior repair, decreased with increasing genital hiatus, such that a genital hiatus of 4.5 cm was associated with 65.8% success (95% confidence interval, 60.1–71.1%).

Conclusion

Concomitant posterior repair at sacrospinous ligament fixation or uterosacral ligament suspension was not associated with surgical success after adjusting for baseline covariates using propensity scores or unadjusted comparison. Posterior repair may not compensate for the pathophysiology that leads to enlarged preoperative genital hiatus, which remains prognostic of prolapse recurrence.

Le texte complet de cet article est disponible en PDF.

Key Words : apical suspension, colpopexy, perineorrhaphy, posterior colporrhaphy, posterior repair, prolapse, propensity score analysis, sacrospinous ligament fixation, transvaginal surgery, uterosacral ligament suspension, variation in practice, vault prolapse


Plan


 C.R.R. receives Research Support from Pelvalon, Solace Therapeutics, Foundation for Female Health Awareness. U.U.A. receives Research Support from Pelvalon. M.G.G. receives Research Support from Boston Scientific on behalf of the Pelvic Floor Disorders Network. D.D.R. receives Research Support from Pfizer. All other authors report no conflict of interest.
 This work was supported by the Eunice Kennedy Shriver National Institute of Child Health and Human Development grants HD041261, HD069013, HD054214, RTII 1606MB, HD041267, HD054241, FP1810/3RG40, HD069010, HD069006, HD069031, and the National Institutes of Health Office of Research on Women’s Health.
 The OPTIMAL trial is registered at clinicaltrials.gov under Registration # NCT00597935.
 Cite this article as: Sutkin G, Zyczynski HM, Sridhar A, et al. Association between adjuvant posterior repair and success of native tissue apical suspension. Am J Obstet Gynecol 2020;222:161.e1-8.


© 2019  Elsevier Inc. Tous droits réservés.
Ajouter à ma bibliothèque Retirer de ma bibliothèque Imprimer
Export

    Export citations

  • Fichier

  • Contenu

Vol 222 - N° 2

P. 161.e1-161.e8 - février 2020 Retour au numéro
Article précédent Article précédent
  • Hypnotherapy or medications: a randomized noninferiority trial in urgency urinary incontinent women
  • Yuko M. Komesu, Ronald M. Schrader, Rebecca G. Rogers, Robert E. Sapien, Andrew R. Mayer, Loren H. Ketai
| Article suivant Article suivant
  • The natural history of urinary incontinence subtypes in the Nurses’ Health Studies
  • Vatche A. Minassian, Kaitlin A. Hagan, Elisabeth Erekson, Andrea M. Austin, Donald Carmichael, Julie P.W. Bynum, Francine Grodstein

Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.

Déjà abonné à cette revue ?

Mon compte


Plateformes Elsevier Masson

Déclaration CNIL

EM-CONSULTE.COM est déclaré à la CNIL, déclaration n° 1286925.

En application de la loi nº78-17 du 6 janvier 1978 relative à l'informatique, aux fichiers et aux libertés, vous disposez des droits d'opposition (art.26 de la loi), d'accès (art.34 à 38 de la loi), et de rectification (art.36 de la loi) des données vous concernant. Ainsi, vous pouvez exiger que soient rectifiées, complétées, clarifiées, mises à jour ou effacées les informations vous concernant qui sont inexactes, incomplètes, équivoques, périmées ou dont la collecte ou l'utilisation ou la conservation est interdite.
Les informations personnelles concernant les visiteurs de notre site, y compris leur identité, sont confidentielles.
Le responsable du site s'engage sur l'honneur à respecter les conditions légales de confidentialité applicables en France et à ne pas divulguer ces informations à des tiers.


Tout le contenu de ce site: Copyright © 2024 Elsevier, ses concédants de licence et ses contributeurs. Tout les droits sont réservés, y compris ceux relatifs à l'exploration de textes et de données, a la formation en IA et aux technologies similaires. Pour tout contenu en libre accès, les conditions de licence Creative Commons s'appliquent.