Atrophy of individual thigh muscles measured by MRI in older adults with knee osteoarthritis: A cross-sectional study - 25/01/20
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Highlights |
• | The ratio of vastus medialis (VM) cross-sectional area (CSA) to quadriceps muscle and that of semi-membranosus (SM) CSA to hamstring were low in individuals with medial knee osteoarthritis. |
• | The thigh region to evaluate muscle atrophy differed by muscles. |
• | The thigh region around the mid-thigh should be analyzed for the VM CSA ratio. |
• | The thigh region at the muscle belly should be analyzed for the SM CSA ratio. |
• | The therapeutic effect of VM and SM hypertrophy on knee osteoarthritis is worth testing. |
Abstract |
Background |
The characteristics of thigh-muscle cross-sectional area (CSA) in older adults with knee osteoarthritis (KOA) remain controversial.
Objectives |
This study aimed to evaluate atrophy of individual thigh muscles in older adults with KOA and to determine which muscle CSA should be measured to detect KOA-related muscle atrophy of the thigh.
Methods |
In older adults, individual thigh-muscle CSA measured by 1.5 Tesla MRI was analyzed at 5% intervals of the femoral length (FL) around the mid-thigh between the proximal 25% of the FL and the distal 25%. Participants with KOA grade≤1 and grade≥2 were compared for ratios of quadriceps muscle (QM) CSA to total thigh, individual QM CSA to QM, and individual hamstring (HAM) CSA to HAM at 5% intervals.
Results |
We included 40 older adults [20 males; mean (SD) age 73.3 (4.7) years; 20 with KOA grade≤1 and 20 with KOA grade≥2]. The ratio of vastus medialis (VM) CSA to QM from the proximal 25% to distal 15% and the ratio of semi-membranosus (SM) CSA to HAM at the distal 10% to 25% were significantly lower with KOA grade≥2 than grade≤1; the effect sizes were 0.34 to 0.67 for VM and 0.40 to 0.60 for SM. The effect sizes were greatest for the ratios of VM CSA to QM at the mid-thigh with 5% intervals and the ratio of SM CSA to HAM at the distal 25%.
Conclusions |
The ratio of VM CSA to QM and/or that of SM CSA to HAM were low and were the best indicators to detect KOA-related muscle atrophy of the thigh. However, to detect KOA-related muscle atrophy, the VM CSA ratio should be analyzed in the thigh region around the mid-thigh, whereas the SM CSA ratio should be analyzed in the thigh region at the muscle belly.
Le texte complet de cet article est disponible en PDF.Keywords : Magnetic resonance imaging, Quadriceps muscle, Hamstring, Muscle cross-sectional area, Knee osteoarthritis
Plan
Vol 63 - N° 1
P. 38-45 - janvier 2020 Retour au numéro
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