The Effect of Extended Continuous Positive Airway Pressure on Changes in Lung Volumes in Stable Premature Infants: A Randomized Controlled Trial - 22/01/20
Abstract |
Objective |
To compare changes in lung volumes, as measured by functional residual capacity (FRC), through to discharge in stable infants randomized to 2 weeks of extended continuous positive airway pressure CPAP (eCPAP) vs CPAP discontinuation (dCPAP).
Study design |
Infants born at ≤32 weeks of gestation requiring ≥24 hours of CPAP were randomized to 2 weeks of eCPAP vs dCPAP when meeting CPAP stability criteria. FRC was measured with the nitrogen washout technique. Infants were stratified by gestational age (<28 and ≥ 28 weeks) and twin gestation. A linear mixed-effects model was used to evaluate the change in FRC between the 2 groups. Data were analyzed blinded to treatment group allocation.
Results |
Fifty infants were randomized with 6 excluded, for a total of 44 infants. Baseline characteristics were similar in the 2 groups. The infants randomized to eCPAP vs dCPAP had a greater increase in FRC from randomization through 2 weeks (12.6 mL vs 6.4 mL; adjusted 95% CI, 0.78-13.47; P = .03) and from randomization through discharge (27.2 mL vs 17.1 mL; adjusted 95% CI, 2.61-17.59; P = .01).
Conclusions |
Premature infants randomized to eCPAP had a significantly greater increase in FRC through discharge compared with those randomized to dCPAP. An increased change in FRC may lead to improved respiratory health.
Trial registration |
ClinicalTrials.gov: NCT02249143.
Le texte complet de cet article est disponible en PDF.Keywords : premature, continuous positive airway pressure, functional residual capacity
Abbreviations : CPAP, Crs, dCPAP, eCPAP, FRC, NICU, OHSU, PFT, PMA
Plan
| Supported in part by NHLBI HL105447, NHLBI HL129060, and NIH UH3OD023288 (to C.M. and K.M.) and Friends of the Doernbecher Foundation and Oregon Clinical and Translational Research Institute (UL1TR000128) from the National Center for Advancing Translational Sciences at the National Institutes of Health (NIH). The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH. The authors declare no conflicts of interest. |
Vol 217
P. 66 - février 2020 Retour au numéro
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