Continuing rotavirus circulation in children and adults despite high coverage rotavirus vaccination in Finland - 15/01/20
, Maria Hemming-Harlo a, b , Carita Savolainen-Kopra c , Haider al-Hello c , Timo Vesikari a Highlights |
• | Rotavirus disease cannot be eliminated with current live rotavirus vaccines. |
• | Rotaviruses continue to circulate despite long-term high coverage mass-vaccination. |
• | Rotavirus disease in the elderly follows the disease in children. |
• | Previously dominant genotype G1P[8] has subsided because of vaccinations. |
Abstract |
Objectives |
To determine occurrence of residual rotavirus (RV) disease in different age groups in Finland after five to nine years of high coverage (≥90%) mass-vaccination with RotaTeqⓇ vaccine, and to examine the vaccine effect on circulating genotypes.
Methods |
Since 2013 all clinical laboratories in the country were obliged to send RV positive stool samples for typing. RVs were genotyped by RT-PCR for VP7 and VP4 proteins, sequenced and compared to reference strains.
Results |
RV continued to circulate throughout the study period at low level with a small increase in 2017–2018. There were three age-related clusters: young children representing primary or secondary vaccine failures, school-age children who may not have been vaccinated, and the elderly. Genotype distribution differed from the pre-vaccination period with a steady decline of G1P[8], emergence of G9P[8] and especially more recently G12P[8]. In the elderly, G2P[4] was predominant but was also replaced by G12P[8] in 2017–18.
Conclusions |
RV vaccination with a high coverage keeps RV disease at low level but does not prevent RV circulation. New RV genotypes have emerged replacing largely the previously predominant G1P[8]. Increase of overall RV activity with emergence of G12P[8] in the latest follow-up season 2017–18 might be a potential alarm sign.
Le texte complet de cet article est disponible en PDF.Keywords : Rotavirus, Vaccination, RotaTeq, Genotype, Surveillance
Plan
Vol 80 - N° 1
P. 76-83 - janvier 2020 Retour au numéro
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