Mechanisms of Matrix Vesicles Mediating Calcification Transition in Diabetic Plaque - 24/12/19
, Lili Zhang, MSc a, 1, Zhen Sun, MSc a, Chen Shao, PhD a, Yukun Li, MSc a, Zhengyang Bao, MSc a, Lele Jing, MSc a, Yue Geng, MSc a, Wen Gu, MSc a, Qiwen Pang, MSc a, Lihua Li, MSc b, ⁎ , Jinchuan Yan, PhD a, ⁎ Résumé |
Vascular calcification is a key character of advanced plaque in diabetic atherosclerosis. Microcalcification induces plaque rupture, whereas macrocalcification contributes to plaque stability. However, there is still no clear explanation for the formation and transition of these two types of calcification. Based on existing work and the latest international progress, this article provides a brief review of four aspects: calcification transition in plaque; matrix vesicle-mediated calcification transition in plaque; regulation mechanism of matrix vesicle-mediated calcification transition in diabetic plaque; and proposal of a new hypothesis, which may offer a new perspective on the study of the mechanism of calcification transition in plaque.
Le texte complet de cet article est disponible en PDF.Keywords : Advanced glycation end products, Matrix vesicles, Vascular calcification, Calcification transition, Atherosclerosis
Plan
Vol 29 - N° 1
P. 112-117 - janvier 2020 Retour au numéro
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