Safety and effectiveness of apheresis in the treatment of infectious diseases: A systematic review - 05/12/19
, David G. Lalloo b, Glen Kennedy c, Stacey Llewellyn a, James S. McCarthy a, cHighlights |
• | Cohort studies, case series and case reports were identified. |
• | The routine use of apheresis in severe P. falciparum malaria is not recommended. |
• | Apheresis may be used as an adjunct in patients hospitalised for Babesia infection. |
• | Apheresis may be used pre chemotherapy in loiasis and microfilarial count >8000/mL. |
Abstract |
Objectives |
Apheresis has been used as adjunctive treatment of severe falciparum malaria, loiasis and babesiosis. This systematic review aimed to investigate the safety and efficacy of apheresis in the treatment of these conditions.
Methods |
MEDLINE, PUBMED, EMBASE and CINAHL databases were searched to identify studies published between January 1969 and March 2018 involving patients treated using apheresis for severe falciparum malaria, loiasis or babesiosis. Data extracted included details about the apheresis intervention, populations, study methods and outcomes relating to efficacy and safety.
Results |
A total of 67 publications met the inclusion criteria and were included in the data synthesis, 36 for malaria (70 cases), 17 for babesiosis (22 cases) and 14 for loiasis (34 cases). Publications were case reports, case series, and cohort studies; there were no randomised controlled trials identified. Potential publication bias was considered to be high.
Conclusions |
Systematic review of the literature suggests that apheresis may be a useful adjunct in the treatment of patients hospitalised for babesiosis, and prior to chemotherapy in loiasis with microfilarial count >8000 parasites/mL. Data does not support the use of apheresis in patients with severe falciparum malaria.
Le texte complet de cet article est disponible en PDF.Keywords : Malaria, Loiasis, Loa loa, Babesia, Babesiosis, Apheresis, Erythrocytapheresis, Red cell exchange, Plasmapheresis, Plasma exchange
Plan
Vol 79 - N° 6
P. 513-520 - décembre 2019 Retour au numéro
Article précédent
- Consensus recommendations for resistance testing in the management of chronic hepatitis C virus infection: Public Health England HCV Resistance Group
- Daniel Bradshaw, Jean L Mbisa, Anna Maria Geretti, Brendan J Healy, Graham S Cooke, Graham R Foster, Emma C Thomson, John McLauchlan, Kosh Agarwal, Caroline Sabin, David Mutimer, Peter Moss, William L Irving, Ellie Barnes, The Hepatitis C Trust, UK
- Hospital clusters of invasive Group B Streptococcal disease: A systematic review
- Simon M Collin, Peter Lamb, Elita Jauneikaite, Kirsty Le Doare, Roberta Creti, Alberto Berardi, Paul T Heath, Shiranee Sriskandan, Theresa Lamagni
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
Déjà abonné à cette revue ?