Sebaceous carcinoma: evidence-based clinical practice guidelines - 03/12/19
Doi : 10.1016/S1470-2045(19)30673-4
Joshua L Owen, MD a, †, Nour Kibbi, MD f, †, Brandon Worley, MD a, g, †, Ryan C Kelm, MD a, Jordan V Wang, MD j, Christopher A Barker, MD l, Ramona Behshad, MD m, Christopher K Bichakjian, ProfMD n, Diana Bolotin, MD p, Jeremy S Bordeaux, ProfMD q, Scott H Bradshaw, MD h, Todd V Cartee, MD r, Sunandana Chandra, MD b, Nancy L Cho, MD s, Jennifer N Choi, MD a, M Laurin Council, MD t, Hakan Demirci, MD o, Daniel B Eisen, ProfMD u, Bita Esmaeli, ProfMD v, Nicholas Golda, MD z, Conway C Huang, MD aa, Sherrif F Ibrahim, MD ab, S Brian Jiang, ProfMD ac, John Kim, ProfMD c, Timothy M Kuzel, ProfMD ad, Stephen Y Lai, ProfMD w, Naomi Lawrence, ProfMD ae, Erica H Lee, MD af, Justin J Leitenberger, MD ag, Ian A Maher, MD ah, Margaret W Mann, MD ai, Kira Minkis, MD aj, Bharat B Mittal, ProfMD d, Kishwer S Nehal, ProfMD af, Isaac M Neuhaus, MD ak, David M Ozog, MD al, Brian Petersen, MD am, Veronica Rotemberg, MD af, Sandeep Samant, ProfMD e, Faramarz H Samie, MD an, Sabah Servaes, MD ao, Carol L Shields, ProfMD k, Thuzar M Shin, MD ap, Joseph F Sobanko, MD ap, Ally-Khan Somani, MD aq, William G Stebbins, MD ar, J Regan Thomas, ProfMD e, Valencia D Thomas, MD y, David T Tse, ProfMD as, Abigail H Waldman, MD at, Michael K Wong, ProfMD x, Y Gloria Xu, MD au, Siegrid S Yu, MD ak, Nathalie C Zeitouni, ProfMD av, Timothy Ramsay, PhD i, Kelly A Reynolds, BA a, Emily Poon, PhD a, Murad Alam, ProfMD a, ⁎ 
a Department of Dermatology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA
b Division of Hematology and Oncology, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA
c Department of Plastic Surgery, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA
d Department of Radiation Oncology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA
e Department of Otolaryngology—Head and Neck Surgery, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA
f Department of Dermatology, Yale School of Medicine, New Haven, CT, USA
g Division of Dermatology, The Ottawa Hospital, Ottawa, ON, Canada
h Department of Pathology and Laboratory Medicine, The Ottawa Hospital, Ottawa, ON, Canada
i The Ottawa Health Research Institute, The Ottawa Hospital, Ottawa, ON, Canada
j Department of Dermatology and Cutaneous Biology, Thomas Jefferson University, Philadelphia, PA, USA
k Ocular Oncology Service, Wills Eye Hospital, Thomas Jefferson University, Philadelphia, PA, USA
l Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY, USA
m Department of Dermatology, Saint Louis University School of Medicine, Saint Louis, MO, USA
n Department of Dermatology, University of Michigan, Ann Arbor, MI, USA
o Department of Ophthalmology and Visual Sciences, Kellogg Eye Center, University of Michigan, Ann Arbor, MI, USA
p Section of Dermatology, The University of Chicago, Chicago, IL, USA
q Department of Dermatology, University Hospitals Cleveland Medical Center, Case Western Reserve University School of Medicine, Cleveland, OH, USA
r Division of Dermatology, Pennsylvania State University, Hershey, PA, USA
s Department of Surgery, Brigham and Women’s Hospital, Harvard University, Boston, MA, USA
t Division of Dermatology, Center for Dermatologic and Cosmetic Surgery, Washington University in Saint Louis, Saint Louis, MO, USA
u Department of Dermatology, University of California Davis, Sacramento, CA, USA
v Orbital Oncology and Ophthalmic Plastic Surgery, Department of Plastic Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
w Departments of Head and Neck Surgery and Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
x Division of Cancer Medicine, Department of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
y Dermatology and Dermatopathology, Department of Dermatology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
z Department of Dermatology, University of Missouri School of Medicine, Columbia, MO, USA
aa Department of Dermatology, University of Alabama, Birmingham, AL, USA
ab Department of Dermatology, University of Rochester, Rochester, NY, USA
ac Department of Dermatology, University of California San Diego, San Diego, CA, USA
ad Division of Hematology, Oncology and Cell Therapy, Department of Internal Medicine, Rush University Medical Center, Chicago, IL, USA
ae Department of Dermatology, Cooper Hospital, Rowan University, Camden, NJ, USA
af Dermatology Service, Memorial Sloan Kettering Cancer Center, New York, NY, USA
ag Department of Dermatology, Oregon Health and Science University, Portland, OR, USA
ah Department of Dermatology, University of Minnesota, Minneapolis, MN, USA
ai Department of Dermatology, University Hospital, Cleveland, OH, USA
aj Department of Dermatology, Weill-Cornell Medical College, New York, NY, USA
ak Department of Dermatology, University of California at San Francisco, San Francisco, CA, USA
al Department of Dermatology, Henry Ford Hospital, Detroit, MI, USA
am Department of Dermatology, Colorado Permanente Medical Group, Denver, CO, USA
an Department of Dermatology, Columbia University Medical Center, New York, NY, USA
ao Department of Radiology, Children’s Hospital of Philadelphia, University of Pennsylvania, Philadelphia, PA, USA
ap Department of Dermatology, Hospital of the University of Pennsylvania, Philadelphia, PA, USA
aq Department of Dermatology, Indiana University School of Medicine, Indianapolis, IN, USA
ar Department of Dermatology, Vanderbilt University Medical Center, Nashville, TN, USA
as Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL, USA
at Brigham and Women’s Hospital Department of Dermatology, Harvard Medical School, Boston, MA, USA
au Department of Dermatology, University of Wisconsin-Madison, Madison, WI, USA
av Department of Dermatology, University of Arizona, Phoenix, AZ, USA
* Correspondence to: Dr Murad Alam, Department of Dermatology, Northwestern University, 676 N St Clair, Suite 1600, Chicago, IL 60611, USA Department of Dermatology Northwestern University 676 N St Clair Suite 1600 Chicago IL 60611 USA
Summary |
Sebaceous carcinoma usually occurs in adults older than 60 years, on the eyelid, head and neck, and trunk. In this Review, we present clinical care recommendations for sebaceous carcinoma, which were developed as a result of an expert panel evaluation of the findings of a systematic review. Key conclusions were drawn and recommendations made for diagnosis, first-line treatment, radiotherapy, and post-treatment care. For diagnosis, we concluded that deep biopsy is often required; furthermore, differential diagnoses that mimic the condition can be excluded with special histological stains. For treatment, the recommended first-line therapy is surgical removal, followed by margin assessment of the peripheral and deep tissue edges; conjunctival mapping biopsies can facilitate surgical planning. Radiotherapy can be considered for cases with nerve or lymph node involvement, and as the primary treatment in patients who are ineligible for surgery. Post-treatment clinical examination should occur every 6 months for at least 3 years. No specific systemic therapies for advanced disease can be recommended, but targeted therapies and immunotherapies are being developed.
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Elsevier Ltd. Tous droits réservés.
Vol 20 - N° 12
P. e699-e714 - décembre 2019 Retour au numéro
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