Adverse Birth Outcomes and Birth Telomere Length: A Systematic Review and Meta-Analysis - 21/11/19
Abstract |
Objectives |
To synthesize previous findings on the difference in birth telomere length between newborns with and without intrauterine growth restriction (IUGR) or with and without preterm birth.
Study design |
We systematically searched 3 databases (PubMed, Embase, and Web of Science) for publications that examined the relationships of IUGR or preterm birth with birth telomere length. We conducted meta-analysis to pool the estimated difference in birth telomere length either between IUGR and non-IUGR or between preterm birth and full-term birth. Subgroup analyses were conducted by tissues (newborn blood vs placenta) and techniques used for telomere length measurement (quantitative polymerase chain reaction [qPCR] vs telomere restriction fragment).
Results |
We included 11 articles on comparing birth telomere length between IUGR (combined n = 227) and non-IUGR (n = 1897) and 7 articles on comparing birth telomere length between preterm birth (n = 182) and full-term birth (n = 1320). We found IUGR was associated with shorter birth telomere length only when birth telomere length was measured in placenta (pooled standardized mean difference [SMD] = −0.85; 95% CI −1.13 to −0.57; IUGR/non-IUGR n = 87/173), but not in newborn blood (pooled SMD = 0.00, 95% CI −0.18 to 0.19; IUGR/non-IUGR n = 148/1733). Birth telomere length was significantly longer in preterm birth than in full-term birth when birth telomere length was measured by qPCR (pooled SMD = 0.40, 95% CI 0.18-0.63; preterm birth/full-term birth n = 137/682) but not by telomere restriction fragment (pooled SMD = 0.05, 95% CI −0.29 to 0.38; preterm birth/full-term birth n = 44/444).
Conclusions |
IUGR is associated with shorter placental telomere length and preterm birth is associated with longer birth telomere length measured by qPCR.
Le texte complet de cet article est disponible en PDF.Keywords : telomere, intrauterine growth restriction, preterm, meta-analysis
Abbreviations : bp, IUGR, LBW, NOS, qPCR, SGA, SMD, TRF
Plan
| The authors declare no conflicts of interest. |
Vol 215
P. 64 - décembre 2019 Retour au numéro
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