Bone Health in Children and Youth with Cystic Fibrosis: A Systematic Review and Meta-Analysis of Matched Cohort Studies - 21/11/19
, Celia Alvarez-Bueno, PhD 1, 2, 3, Dimitris Vlachopoulos, PhD 4, Vicente Martínez-Vizcaíno, PhD, MD 1, 5, Luis Gracia-Marco, PhD 6, 7Abstract |
Objective |
To assess the evidence regarding the differences in areal bone mineral density (aBMD) between children and adolescents with cystic fibrosis (CF) compared with their healthy peers, based on data from longitudinal studies.
Study design |
We searched MEDLINE, SPORTDiscus, the Cochrane Library, PEDro (Physiotherapy Evidence Database), and Embase databases. Observational studies addressing the change of aBMD in children with CF and healthy children and adolescents were eligible. The DerSimonian and Laird method was used to compute pooled estimates of effect sizes (ES) and 95% CIs for the change of whole body (WB), lumbar spine (LS), and femoral neck (FN) aBMD.
Results |
Six studies with participants with CF and 26 studies with healthy participants were included in the systematic review and meta-analysis. For the analysis in children with CF, the pooled ES for the change of WB aBMD was 0.29 (95% CI –0.15 to 0.74), for the change of LS aBMD was 0.13 (95% CI –0.16 to 0.41), and for the change of FN aBMD was 0.09 (95% CI –0.39 to 0.57). For the analysis in healthy children, the pooled ES for the change of WB aBMD was 0.37 (95% CI 0.26-0.49), for the change of LS aBMD was 0.13 (95% CI –0.16 to 0.41), and for the change of FN aBMD was 0.52 (95% CI 0.19-0.85).
Conclusions |
aBMD development might not differ between children and adolescents with CF receiving medical care compared with their healthy peers. Further longitudinal studies in a CF population during growth and development are required to confirm our findings.
Le texte complet de cet article est disponible en PDF.Keywords : adolescence, bone mass, densitometry, pediatric, youth
Abbreviations : aBMD, CF, DXA, ES, FN, LS, MOOSE, WB
Plan
| L.M. is supported by Programa de Captación de Talento - UGR Fellows, from the University of Granada. The authors declare no conflicts of interest. |
Vol 215
P. 178 - décembre 2019 Retour au numéro
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