Inflammatory Bowel Disease in Children with Elevated Serum Gamma Glutamyltransferase Levels - 21/11/19
Abstract |
Objective |
To assess the characteristics of inflammatory bowel disease and disease prognosis among children with elevated gamma glutamyltransferase (GGT) and primary sclerosing cholangitis (PSC)-ulcerative colitis (UC).
Study design |
Our longitudinal, population-based cohort comprised all children and young adults diagnosed with UC in the Canadian province of Manitoba between 2011 and 2018. Diagnosis of PSC was confirmed based on a combination of cholestatic biochemical markers and cholangiographic features. The Fisher exact test with Bonferroni correction was used to examine the relationship between categorical variables.
Results |
We enrolled 95 children with UC/Inflammatory bowel disease-unclassified with a median age at diagnosis of 14 years (IQR: 10.4-15.9 years) and 1399 person-years follow-up. Among them, 9 children developed PSC-UC, with an incidence rate of 6.43 new cases per 1000 person-years. In this cohort, 8 (72.7%) of 11 children with high baseline serum GGT levels developed PSC-UC in comparison with 1 (1.2%) of 84 children with normal serum GGT levels at baseline (P < .001). All children with high serum GGT levels at diagnosis had pancolitis in comparison with 63.9% of children with normal serum GGT levels (P = .01). Children with high serum GGT levels were more likely to be perinuclear neutrophil antibodies-positive than those with normal levels (90.9% vs 52.0%, P = .01).
Conclusions |
Our findings indicated that pediatric patients with UC and with even mild elevations of serum GGT levels, especially at baseline, might be predisposed to develop PSC.
Le texte complet de cet article est disponible en PDF.Keywords : ulcerative colitis, primary sclerosing cholangitis, pediatrics, biomarkers
Abbreviations : aHR, CD, GGT, IBD, IBD-U, pANCA, PSC, PUCAI, UC
Plan
| Supported through a grant from the Children's Hospital Research Institute of Manitoba (CHRIM) and the Children’s Hospital Foundation, Winnipeg. A.C. was supported by the Children's Health Research Institute of Manitoba graduate studentship (in collaboration with Research Manitoba) for the year 2017-2018 and currently receives support from the Women’s Health Research Foundation of Canada (WHRF) graduate scholarship for the year 2018-19. M.D. is supported by the National Center for Advancing Translational Sciences of the United States National Institutes of Health under Award Number KL2TR002539. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. The authors declare no conflicts of interest. |
Vol 215
P. 144 - décembre 2019 Retour au numéro
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