Atypical ubiquitin-binding protein SHARPIN promotes breast cancer progression - 01/10/19
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
| pages | 6 |
| Iconographies | 4 |
| Vidéos | 0 |
| Autres | 0 |
Highlights |
• | Ubiquitination plays an important role in the development of breast cancer. |
• | SHARPIN promotes normal tissue development, inflammation and homeostasis. |
• | SHARPIN as a ubiquitin-related protein, can promote breast cancer through P53 and ER signaling pathways. |
Abstract |
Breast cancer ranks first among female malignancies worldwide, and estrogen receptor-positive (ER+) breast cancer is the leading cause of cancer death in women. Abnormal oncogenic signaling has important effects on the development of breast cancer, such as ERα/ ESR1 (estrogen receptor alpha), PTEN (gene of phosphate and tension homology deleted on chromsome ten), NFκB(nuclear factor κB), and tumor protein p53 (p53 / TP53). SHARPIN is a ubiquitin-related protein that has important regulatory functions in inflammation control, immune organ development, and cancer development. SHARPIN is highly expressed in many cancers, especially in breast cancer. It plays an important role in controlling important carcinogenic pathways in breast cancer, such as p53 and ERα. This review emphasizes the functional role of SHARPIN and the recent advances in the molecular mechanisms by which SHARPIN regulates breast cancer development through ubiquitination.
Le texte complet de cet article est disponible en PDF.Keywords : Breast cancer, SHARPIN, ER ɑ, P53, Ubiquitination
Plan
Vol 119
Article 109414- novembre 2019 Retour au numéro
Article précédent
- The characteristics of lung cancer in Xuanwei County: A review of differentially expressed genes and noncoding RNAs on cell proliferation and migration
- Rong Li, Yan Liu, Tiying Wang, Jiadai Tang, Lin Xie, Zhihong Yao, Kechen Li, Yedan Liao, Ling Zhou, Zhenqin Geng, Zeyong Huang, Zuozhang Yang, Lei Han
- Regulatory roles of the miR-200 family in neurodegenerative diseases
- Jie Fu, Lilei Peng, Tao Tao, Yangmei Chen, Zuoxiao Li, Jinglun Li
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’achat d’article à l’unité est indisponible à l’heure actuelle.
Déjà abonné à cette revue ?