The characteristics of lung cancer in Xuanwei County: A review of differentially expressed genes and noncoding RNAs on cell proliferation and migration - 01/10/19

Doi : 10.1016/j.biopha.2019.109312

Rong Li ^a,^{^{1
These authors contributed equally to this work and should be considered as co-first authors.}}, Yan Liu ^b,^{^{1
These authors contributed equally to this work and should be considered as co-first authors.}}, Tiying Wang ^b,^{^{1
These authors contributed equally to this work and should be considered as co-first authors.}}, Jiadai Tang ^a,^{^{1
These authors contributed equally to this work and should be considered as co-first authors.}}, Lin Xie ^a,^⁎ , Zhihong Yao ^b, Kechen Li ^b, Yedan Liao ^a, Ling Zhou ^b, Zhenqin Geng ^a, Zeyong Huang ^c, Zuozhang Yang ^b,^⁎ , Lei Han ^b
^a Department of Medical Oncology, The Third Affiliated Hospital of Kunming Medical University (Cancer Hospital of Yunnan Province), Kunming, Yunnan, 650118, China
^b Bone and Soft Tissue Tumors Research Center of Yunnan Province, Department of Orthopaedics, The Third Affiliated Hospital of Kunming Medical University (Cancer Hospital of Yunnan Province), Kunming, Yunnan, 650118, China
^c Medical School, Kunming University of Science and Technology, Kunming, Yunnan, 650504, China

^⁎Corresponding authors.

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Abstract

The occurrence of lung cancers is the highest in Xuanwei County, Yunnan province, China, especially among nonsmoking women. Domestic combustion of smoky coal induces serious indoor air pollution and is considered to be the main cause of human lung cancers. The occurrence of lung cancer in Xuanwei County has unique characteristics, such as the high morbidity in nonsmoking women or people with no family history. In the present review, we summarize advances in identification of differentially expressed genes, regulatory lncRNAs and miRNAs in cell proliferation and migration of lung cancers in Xuanwei County. Moreover, several regulatory differentially expressed genes (DEGs) or noncoding RNAs have diagnostic and prognostic significance for lung cancers in Xuanwei County and have the potential to serve as biomarkers.

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Abbreviations : NSCLC, LncRNA, MiRNA, TNM, TTF-1, CAR10, XWCL-05, TDP1, EGFR, ALK, Atg, DSB, PDAC, HMGA1, CAV1