Investigating the effects and possible mechanisms of danshen- honghua herb pair on acute myocardial ischemia induced by isoproterenol in rats - 18/09/19
, Peng-Fei Wang a, Ji-Qing Bai a, ⁎ , Su Gao a, Ya-Heng Wang a, Li-Na Quan a, Fang Wang a, Xiao-Ting Wang a, Jin Wang a, Yun-Dong Xie aBienvenue sur EM-consulte, la référence des professionnels de santé.
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Abstract |
Danshen (salvia miltiorrhiza) and honghua(Carthamus tinctorius) were traditional herb pair with promoting blood circulation and removing blood stasis actions, in China. Both were widely used to treat cardiovascular diseases (CVD) for hundreds years, especially shown definite advantage in the treatment of ischemic heart disease (IHD). However, the mechanism of danshen-honghua herb pair (DHHP) in the treatment of IHD was still unclear. This study was focused on examining the effects and possible mechanisms of DHHP in rats with acute myocardial ischemia induced by isoproterenol (ISO). The results suggested that DHHP significantly ameliorated the myocardial tissue abnormalities, notablely inhibited the elevation of lactate dehydrogenase (LDH), creatine kinase (CK), aspartate aminotransferase (AST), creatinekinase isoenzyme (CK-MB) and cardiac troponin T (CTn-T) in plasma, obviously decreased the plasma levels of Tumor Necrosis Factor α (TNF-α), outstandingly inhibited the reduction of superoxide dismutase (SOD), catalase (CAT) caused by ISO, significantly inhibited the high expression of Bcl-2 assaciated X protein (Bax) and nuclear transcriptionfactor-κBP65 (NF-κBP65) protein, significantly induced the low expression of B-cell lymphoma-2 (Bcl–2) protein in acute myocardial ischemia rats. DHHP can obviously ameliorate hemodynamic parameters. In summary, DHHP can significantly improve myocardial ischemia in acute myocardial ischemia model rats caused by ISO. Anti-free radicals, anti-peroxidation, inhibition of cell apoptosis and anti– inflammation maybe are the potential mechanisms of DHHP anti-myocardial ischemia in acute myocardial ischemia rats in duced by ISO.
Le texte complet de cet article est disponible en PDF.Abbreviations : AST, Bcl-2, Bax, CVD, CK, CK-MB, CTn-T, CAT, HR, IHD, ISO, IL-6, LDH, LVSP, LVEDP, NF-κBP65, NSTE-ACS, SIHD, STEMI, SOD, TNF-α, +dP/dtmax and -dP/dtmax
Keywords : Salvia miltiorrhiza, Carthamustinctorius, Herb pair, Acute myocardial ischemia, Protective effects, Potential, Mechanism
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Vol 118
Article 109268- octobre 2019 Retour au numéro
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