FALEC exerts oncogenic properties to regulate cell proliferation and cell-cycle in endometrial cancer - 18/09/19
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
| pages | 4 |
| Iconographies | 4 |
| Vidéos | 0 |
| Autres | 0 |
Graphical abstract |
Highlights |
• | FALEC is up-regulated in endometrial cancer tissues and cells. |
• | FALEC expression is associated with clinical stage and tumor size. |
• | Silencing FALEC expression inhibits cell proliferation and arrest cell cycle in endometrial cancer. |
Abstract |
Focally amplified lncRNA on chromosome 1 (FALEC) is novel lncRNA located in a focal amplicon on chromosome 1q21.2, and has been identified as an oncogenic properties in a variety of human cancers. However, there was no report about the expression pattern and biological function of FALEC in endometrial cancer. In our research, FALEC expression was increased in endometrial cancer tissue samples and cell lines compared with corresponding paracancerous normal tissue samples and cell line, respectively. Furthermore, we investigated the clinical significance of FALEC in endometrial cancer patients, and found endometrial cancer patients with advanced clinical stage or large tumor size had higher levels of FALEC expression than those with early clinical stage or small tumor size. The in vitro studies showed silencing of FALEC expression inhibited cell proliferation and arrested cell cycle at G0/G1. In conclusion, FALEC is overexpressed in endometrial cancer tissues and cells, and involved in regulating cell proliferation and cell-cycle.
Le texte complet de cet article est disponible en PDF.Keywords : lncRNA, FALEC, FAL1, Biomarker, Endometrial cancer
Plan
Vol 118
Article 109212- octobre 2019 Retour au numéro
Article précédent
- Upregulation of BTF3 affects the proliferation, apoptosis, and cell cycle regulation in hypopharyngeal squamous cell carcinoma
- Yang Zhang, Neil Gross, Zufei Li, Gaofei Yin, Qi Zhong, Chuan Liu, Zhigang Huang
- The protective effect of icariin and phosphorylated icariin against LPS-induced intestinal epithelial cells injury
- Wen Xiong, Haoyue Ma, Zhu Zhang, Meilan Jin, Jian Wang, Yuwei Xu, Zili Wang
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’achat d’article à l’unité est indisponible à l’heure actuelle.
Déjà abonné à cette revue ?