Anesthetic propofol blunts remote preconditioning of trauma-induced cardioprotection via the TRPV1 receptor - 18/09/19
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Highlights |
• | Anesthetic propofol interfere with the cardioprotective effects induced by remote preconditioning of trauma (RPCT). |
• | Cardiac TRPV1 activation may be involved in RPCT induced cardioprotective effects. |
• | Propofol should be carefully used as an anesthetic choice while conducting RPCT induced cardioprotection. |
Abstract |
Remote preconditioning of trauma (RPCT) by surgical incision is an effective cardioprotective strategy via the transient receptor potential vanilloid 1 (TRPV1) channel as a form of remote ischemic preconditioning (RIPC). However, cardioprotection by RIPC has been shown to be completely blocked by propofol. We thus hypothesized that propofol may interfere with RPCT induced cardioprotection, and that RPCT induces cardioprotection via the cardiac TRPV1 channel. Male Sprague-Dawley rats were subjected to 30 min of myocardial ischemia followed by 2 h of reperfusion. RPCT was achieved by a transverse abdominal incision. Additionally, propofol or the TRPV1 receptor inhibitor capsazepine (CPZ) was given before RPCT. Infarct size was assessed by triphenyltetrazolium staining. Heart TRPV1 expression was detected by Western blot and immunofluorescence. RPCT significantly reduced infarct size compared to control treatment (45.6 ± 4% versus 65.4 ± 2%, P < 0.01). This protective effect of RPCT was completely abolished by propofol and CPZ. TRPV1 channels are present in the heart. Therefore, cardioprotection by RPCT is also abolished by propofol, and cardiac TRPV1 mediates this cardioprotection.
Le texte complet de cet article est disponible en PDF.Keywords : Remote preconditioning, Incision, Propofol, Myocardial infarction, TRPV1
Plan
Vol 118
Article 109308- octobre 2019 Retour au numéro
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