Cutaneous angioimmunoblastic T-cell lymphoma: Epstein-Barr virus positivity and its effects on clinicopathologic features - 12/09/19
Abstract |
Background |
Epstein-Barr virus (EBV) positivity frequently presents in patients with nodal angioimmunoblastic T-cell lymphoma (AITL). However, the presence of EBV in skin lesions and its clinicopathologic significance have not been evaluated.
Objective |
To analyze the clinical and histopathologic features of cutaneous AITL and evaluate EBV positivity in skin tissue and its effects on clinicopathologic features of AITL.
Methods |
Clinicopathologic variables in patients with cutaneous AITL were analyzed and compared depending on EBV in situ hybridization status in skin lesions by using patients' medical records.
Results |
Of the 86 patients with AITL, 42 had a cutaneous presentation. In situ hybridizations positive for EBV were noted in 19 of 42 patients with cutaneous AITL. EBV positivity was more common in papular and nodular skin lesions than other cutaneous morphologies, such as nonspecific rash or purpuric patches. An EBV-positive in situ hybridization was associated with a pattern of dense, superficial and deep infiltrates of pleomorphic, large-sized, atypical lymphocytes. EBV positivity in skin lesions was an independent negative prognostic factor in patients with AITL.
Limitations |
Retrospective study at a single institution.
Conclusion |
EBV-positive cutaneous AITL is associated with distinctive clinicopathologic features.
Le texte complet de cet article est disponible en PDF.Key words : angioimmunoblastic T-cell lymphoma, Epstein-Barr virus, outcome, prognostic factor, skin, survival
Abbreviations used : AITL, BCL-6, EBV, LDH, LN, OS, PD-1, TFH
Plan
| Drs Woo J. Lee and Kwang H. Won contributed equally as first authors. |
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| Funding sources: Supported by Asan Life Science Institute (2017-474). |
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| Conflicts of interest: None disclosed. |
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| Reprints not available from the authors. |
Vol 81 - N° 4
P. 989-997 - octobre 2019 Retour au numéro
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