Platinum rechallenge in recurrent head and neck squamous cell carcinoma after primary chemoradiation - 05/09/19
, I. Licaj c, B. Gery a, d, R. Gervais a, b, C. Florescu a, d, E. Babin e, D. De Raucourt a, f, A. Johnson a, b, J. Thariat a, dBienvenue sur EM-consulte, la référence des professionnels de santé.
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Abstract |
Objective |
To evaluate platinum rechallenge efficacy and tolerance in patients presenting recurrent head and neck squamous cell carcinoma (HNSCC) after platinum-based chemoradiation.
Materials and methods |
We retrospectively included all patients treated from 2007 to 2016 by platinum-based polychemotherapy for recurrence of HNSCC previously treated by primary or postsurgical platinum-based chemoradiation. The primary end-point was disease control rate (DCR) on platinum rechallenge.
Results |
Forty-five patients were included. Median disease-free interval (DFI) after chemoradiation was 5.7 months. DCR on platinum rechallenge was 40%. Progression-free survival at recurrence was 3.7 months and overall survival 5.0 months. DCR in patients with recurrence within 6 months of chemoradiotherapy was 47.8%. DFI>4.5 months was associated with better DCR: 28.5% versus 54.8%; P=0.0311.
Conclusion |
Platinum rechallenge provided good DCR in recurrent HNSCC after chemoradiation.
Le texte complet de cet article est disponible en PDF.Keywords : Head and neck cancer, Recurrence, Cisplatin, Carboplatin
Plan
Vol 136 - N° 4
P. 257-261 - septembre 2019 Retour au numéro
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