Early detection of acral melanoma: A review of clinical, dermoscopic, histopathologic, and molecular characteristics - 15/08/19

Doi : 10.1016/j.jaad.2019.01.081

Claudia C. Darmawan, MBBS ^a,^b, Gwanghyun Jo, MD ^a,^b, Sara E. Montenegro, MD ^a,^b, Yoonjin Kwak, MD, PhD ^c, Lee Cheol, MD, PhD ^c, Kwang Hyun Cho, MD, PhD ^d, Je-Ho Mun, MD, PhD ^a,^b,^⁎
^a Department of Dermatology, College of Medicine, Seoul National University, Seoul, Korea
^b Institute of Human-Environment Interface Biology, Seoul National University, Seoul, Korea
^c Department of Pathology, College of Medicine, Seoul National University, Seoul, Korea
^d Department of Dermatology, Mediplex Sejong Hospital, Incheon, Korea

^∗Correspondence to: Je-Ho Mun, MD, PhD, Department of Dermatology, Seoul National University College of Medicine, 101 Daehak-ro, Jongno-gu, Seoul 110-744, Korea.Department of DermatologySeoul National University College of Medicine101 Daehak-ro, Jongno-guSeoul110-744Korea

Abstract

Acral lentiginous melanoma is a distinct subtype of melanoma on acral skin. Patient presentation at later stages and delayed diagnosis by physicians contribute to a worse associated prognosis and survival rate. Despite our progress in understanding the key features of this disease, the diagnosis of early-stage acral melanoma is still challenging. It is essential to integrate clinical, dermoscopic, and histologic findings in the diagnosis of acral lentiginous melanoma. In addition, molecular studies can be helpful. In this review, we have summarized our current understanding of this disease entity from articles that were published between 1969 and 2018. We have outlined clinical and dermoscopic features as well as pathologic and molecular findings regarding acral melanoma and have presented an algorithm for diagnosis. Understanding and integrating these characteristics may assist clinicians in the early detection of acral melanomas.

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Key words : acral melanoma, algorithm, dermoscopy, diagnosis, foot, genetics, histopathology, melanoma, molecular, review

Abbreviations used : ALM, AM, AMF, CM, FISH, PRP

Plan

Histopathology review

Molecular findings

Conclusions

	Funding sources: None.
	Conflicts of interest: None disclosed.
	Reprints not available from the authors.

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Vol 81 - N° 3

P. 805-812 - septembre 2019 Retour au numéro

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Early detection of acral melanoma: A review of clinical, dermoscopic, histopathologic, and molecular characteristics - 15/08/19

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