Treatment with andrographolide sulfonate provides additional benefits to imipenem in a mouse model of Klebsiella pneumoniae pneumonia - 31/07/19
, Nan Liu a, b, ⁎ Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
| pages | 10 |
| Iconographies | 15 |
| Vidéos | 0 |
| Autres | 0 |
Highlights |
• | We first investigate that the effects of andrographolide sulfonate (AS) in mouse model of pneumonia caused by acute bacterial infection and We show that pretreatment with AS significantly attenuate infiltration of inflammatory cells. |
• | Combined treatment with AS and imipenem significantly inhibited the mortality in mice infected with K. pneumoniae, which shows important clinical significance. |
• | Combined therapy with AS and imipenem attenuate infiltration of inflammatory cells further and significantly decrease level of MCP-5 compared to treatment with drugs alone. |
Abstract |
Klebsiella pneumoniae is a primary cause of community-acquired and nosocomial respiratory infections, and K. pneumoniae resistance to the current treatment approach with carbapenem is worsening. Andrographolide is a natural diterpenoid from Andrographis paniculata that was shown to exert anti-inflammatory activity. We herein show that pretreatment with a water-soluble andrographolide sulfonate significantly attenuate lung injury and infiltration of inflammatory cells. Interestingly, mice receiving combined treatment with andrographolide sulfonate displayed perfect survival rate than the mice treatment with imipenem alone, and monocyte chemotactic protein 5 (MCP-5) level was decreased further. These findings suggest that andrographolide sulfonate could as a potential synergist for antibiotic treatment of bacteria-induced inflammation.
Le texte complet de cet article est disponible en PDF.Abbreviations : K.pneumoniae, CPS, LPS, AS, IL, NF, LB, CFUs, HBSS, GM-CSF, BMDM, PBS, MOI, BALF, MGG, H&E, MPO, TNF, MCP-5
Keywords : Klebsiella pneumoniae, Andrographolide sulfonate, Carbapenem, Lung inflammation, Combination therapy, MCP-5
Plan
Vol 117
Article 109065- septembre 2019 Retour au numéro
Article précédent
- Anticancer activity of synthetic (±)-kusunokinin and its derivative (±)-bursehernin on human cancer cell lines
- Thidarath Rattanaburee, Tienthong Thongpanchang, Krittaphat Wongma, Aman Tedasen, Yaowapa Sukpondma, Potchanapond Graidist
- LncRNA STXBP5-AS1 suppressed cervical cancer progression via targeting miR-96-5p/PTEN axis
- Shiqing Shao, Chen Wang, Shelian Wang, Hongxia Zhang, Yongyan Zhang
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’achat d’article à l’unité est indisponible à l’heure actuelle.
Déjà abonné à cette revue ?