Expression of lymphocyte-activating gene 3 and T-cell immunoreceptor with immunoglobulin and ITIM domains in cutaneous melanoma and their correlation with programmed cell death 1 expression in tumor-infiltrating lymphocytes - 21/06/19
, Ye Jin Lee, MD, Myoung Eun Choi, MD, Kyung A. Yun, MSc, Chong Hyun Won, MD, PhD, Mi Woo Lee, MD, PhD, Jee Ho Choi, MD, PhD, Sung Eun Chang, MD, PhD ⁎ Abstract |
Background |
Lymphocyte-activating gene 3 (LAG-3) and T-cell immunoreceptor with immunoglobulin and immunoreceptor tyrosine-based inhibition motif (TIGIT) domains are emerging checkpoint proteins.
Objective |
We evaluated LAG-3 and TIGIT protein expression patterns, correlated these patterns with programmed cell death 1 (PD-1) protein expression, and determined their effects on clinicopathologic characteristics and biologic responses in melanoma.
Methods |
Diagnostic tissue from 124 patients with melanoma were evaluated for LAG-3, TIGIT, and PD-1 expression by immunohistochemistry. Clinicopathologic features and survival were analyzed according to the expression of LAG-3, TIGIT, and PD-1.
Results |
LAG-3 and TIGIT expression on tumor-infiltrating lymphocytes were significantly correlated with that of PD-1 and was also significantly associated with negative prognostic factors: deeper Breslow thickness, lymph node involvement, and advanced stage of disease. However, PD-1 expression was not associated with clinicopathologic variables of prognostic significance. High expression of either LAG-3 or TIGIT was associated with worse survival. Subgroup analysis on the basis of Breslow thickness showed that both LAG-3 and TIGIT have prognostic significance regardless of tumor thickness. High expression of PD-1 was not predictive of survival.
Limitations |
Retrospective study in a single institution and possibility of type 1 error.
Conclusion |
Expression of LAG-3 and TIGIT represents an independent unfavorable prognostic factor in cutaneous melanoma.
Le texte complet de cet article est disponible en PDF.Key words : LAG-3, melanoma, PD-1, survival, TIGIT, tumor-infiltrating lymphocytes
Abbreviations used : AJCC, CI, HR, LAG-3, OS, PD-1, PD-L1, PFS, TIGIT, TILs
Plan
| Dr W.J. Lee and Dr Chang contributed equally as corresponding authors. |
|
| Funding sources: Supported by a 2016 Amorepacific-KDA grant. |
|
| Conflicts of interest: None disclosed. |
|
| Reprints not available from the authors. |
Vol 81 - N° 1
P. 219-227 - juillet 2019 Retour au numéro
Article précédent
- Use of 5-0 Fast Absorbing Gut versus 6-0 Fast Absorbing Gut during cutaneous wound closure on the head and neck: A randomized evaluator-blinded split-wound comparative effectiveness trial
- Aunna Pourang, Milene K. Crispin, Ashley K. Clark, April W. Armstrong, Raja K. Sivamani, Daniel B. Eisen
- Recommendations for the definition, evaluation, and treatment of nail psoriasis in adult patients with no or mild skin psoriasis: A dermatologist and nail expert group consensus
- Dimitrios Rigopoulos, Robert Baran, Soumiya Chiheb, Carlton Ralph Daniel, Nilton Di Chiacchio, Stamatis Gregoriou, Chander Grover, Eckart Haneke, Matilde Iorizzo, Marcel Pasch, Bianca Maria Piraccini, Phoebe Rich, Bertrand Richert, Natalia Rompoti, Adam I. Rubin, Archana Singal, Michela Starace, Antonella Tosti, Ioanna Triantafyllopoulou, Martin Zaiac
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
Déjà abonné à cette revue ?