Proanthocyanidins: A comprehensive review - 16/06/19

Doi : 10.1016/j.biopha.2019.108999

Abdur Rauf ^a, Muhammad Imran ^b, Tareq Abu-Izneid ^c, Iahtisham-Ul-Haq ^d, Seema Patel ^e, Xiandao Pan ^f,^⁎ , Saima Naz ^g, Ana Sanches Silva ^h, Farhan Saeed ⁱ, Hafiz Ansar Rasul Suleria ^j
^a Department of Chemistry, University of Swabi, Anbar, KPK, Pakistan
^b University Institute of Diet & Nutritional Sciences, Faculty of Allied Health Sciences, The University of Lahore, Pakistan
^c Department of Pharmaceutical Sciences, College of Pharmacy, Al Ain University of Science and Technology, Al Ain Campus, UAE
^d Department of Diet and Nutritional Sciences, Faculty of Health and Allied Sciences, Imperial College of Business Studies, Lahore, Pakistan
^e Bioinformatics and Medical Informatics Research Center, San Diego State University, San Diego, 92182, USA
^f Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100050, China
^g Department of Biotechnology, Woman University Mardan, Mardan, KPK, Pakistan
^h National Institute for Agricultural and Veterinary Research, 4485-655, Vila do Conde, Portugal
ⁱ Department of Food Science, Institute of Home and Food Sciences, Government College University, Faisalabad, Pakistan
^j School of Agriculture and Food, The University of Melbourne, Parkville, VIC, 3010, Australia

^⁎Corresponding author.

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Abstract

Proanthocyanidins are condensed tannins with various pharmacological properties. These phytochemicals are considered as ‘offense and defense molecules because of their human health benefits. The validation of their diverse health aspects, namely, antioxidant, anticancer, antidiabetic, neuroprotective, and antimicrobial has earned them repute in thermochemistry. Proanthocyanidins are oligo- or polymers of monomeric flavan-3-ols produced as an end product of flavonoid biosynthetic pathway. Agricultural wastes and food processing wastes contain immense amount of proanthocyanidins, exploitation of which can be a sustainable source of dietary supplements and functional ingredients. The current review article discusses recent developments in the health promoting properties of proanthocyanidins and the associated hurdles.

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Keywords : Condensed tannin, Bio-active compound, Antioxidant capacity, Anticancer, Antidiabetic, Cardiovascular disease

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Introduction

Biological potential of proanthocyanidins

Lipid lowering and anti-obesity

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Vol 116

Article 108999- août 2019 Retour au numéro

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Proanthocyanidins: A comprehensive review - 16/06/19

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