LINC00909 promotes tumor progression in human glioma through regulation of miR-194/MUC1-C axis - 16/06/19

Doi : 10.1016/j.biopha.2019.108965

Zhentao Liu ^a,^b,^{^{1
The authors are co-first authors and contributed equally to this work.}}, Chengyin Lu ^a,^{^{1
The authors are co-first authors and contributed equally to this work.}}, Hongkang Hu ^a,^{^{1
The authors are co-first authors and contributed equally to this work.}}, Zheng Cai ^a,^c, Qiang Liang ^a, Wei Sun ^a, Lei Jiang ^a,^⁎ , Guohan Hu ^a,^⁎
^a Department of Neurosurgery, Shanghai Changzheng Hospital, Second Military Medical University, Shanghai, 200003, China
^b Department of Neurosurgery, 91 Central Hospital of People’s Liberation Army, Jiaozuo Henan Province, 454150, China
^c Department of Pharmaceutics, Shanghai Changhai Hospital, Second Military Medical University, Shanghai, 200433, China

^⁎Corresponding authors.

Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.

pages	10
Iconographies	8
Vidéos	0
Autres	0

Abstract

Long non‐coding RNAs (lncRNAs) play important roles in tumor progression. Whereas the roles and underlying mechanisms of LINC00909 (a newly discovered lncRNA) are still unclear in glioma progression. In the present study, we identified that LINC00909 expression was significantly elevated in glioma tissues and cell lines. High LINC00909 expression was associated with advanced WHO grade, high Karnofsky Performance Score (KPS), and poor prognosis in patients with glioma. Function assays showed that LINC00909 depletion inhibited glioma cells proliferation, invasion in vitro and reduced tumor growth in vivo. In the mechanism, we found that LINC00909 could act as a ceRNA to interact with miR-194 and thereby up‐regulate the expression of MUC1-C, thus promoting the proliferation and invasion of glioma cells. Collectively, these data demonstrated that LINC00909/miR-194/MUC1-C axis regulated glioma progression and might act as a novel therapeutic target.

Le texte complet de cet article est disponible en PDF.

Keywords : Glioma, LINC00909, miR-194, MUC1-C, ceRNA

Plan

Export

Vol 116

Article 108965- août 2019 Retour au numéro

Article précédent

HMGB1/RAGE pro-inflammatory axis promotes vascular endothelial cell apoptosis in limb ischemia/reperfusion injury
Lei Mi, Ying Zhang, Yugang Xu, Xiao Zheng, Xia Zhang, Zhu Wang, Ming Xue, Xing Jin

| Article suivant

Thalidomide ameliorates rosacea-like skin inflammation and suppresses NF-κB activation in keratinocytes
Mengting Chen, Hongfu Xie, Zhaohui Chen, San Xu, Ben Wang, Qinqin Peng, Ke Sha, Wenqin Xiao, Tangxiele Liu, Yiya Zhang, Ji Li, Zhili Deng

Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.

Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’achat d’article à l’unité est indisponible à l’heure actuelle.

Déjà abonné à cette revue ?

connectez-vous ou créez un compte

LINC00909 promotes tumor progression in human glioma through regulation of miR-194/MUC1-C axis - 16/06/19

Abstract

Plan

Export citations

Fichier

Contenu

Accès rapides

Mon compte

Aide & support

Plateformes Elsevier Masson

Déclaration CNIL