Antiviral activity of brequinar against foot-and-mouth disease virus infection in vitro and in vivo - 16/06/19
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
| pages | 6 |
| Iconographies | 7 |
| Vidéos | 0 |
| Autres | 0 |
Highlights |
• | Brequinar shows antiviral activity against FMDV in vitro, including two different serotypes of FMDV. |
• | The antiviral effect of brequinar occurred in the early phases of FMDV replication. |
• | The antiviral effect of brequinar could be attenuated by uridine supplementation |
• | In vivo activity of brequinar was confirmed in a mouse model of infection. |
Abstract |
Foot-and-mouth disease (FMD) is one of the most highly contagious animal disease that affects cloven-hoofed animals. However, the FMD vaccine does not provide effective protection until adaptive immune protection elicited by the vaccination occurs. Therefore, an alternative application of antiviral agents for inhibition of the FMD virus (FMDV) is needed. Here, we demonstrated that brequinar could exhibit antiviral activity in swine kidney cells (IBRS-2 cells) infected with two different FMDV serotypes. Subsequently, in vivo activity of brequinar was confirmed in a mouse model of infection. Specifically, brequinar at a concentration of 50 μg, provided 25% protection for 5 days following FMDV challenge. These results suggested that brequinar could be used as effective antiviral agent against FMD.
Le texte complet de cet article est disponible en PDF.Keywords : Foot and mouth disease virus, Antiviral activity, Brequinar, Suckling mouse, in vivo
Plan
Vol 116
Article 108982- août 2019 Retour au numéro
Article précédent
- Apoptosis induction and AKT/NF-κB inactivation are associated with regroafenib-inhibited tumor progression in non-small cell lung cancer in vitro and in vivo
- Mao-Chi Weng, Ming-Hsin Li, Jing Gung Chung, Yu-Chang Liu, Jeng-Yuan Wu, Fei-Ting Hsu, Hsin-Ell Wang
- Ginsenoside Rg1 promotes sleep in rats by modulating the noradrenergic system in the locus coeruleus and serotonergic system in the dorsal raphe nucleus
- Ya-Ping Xu, Xiang-Yu Cui, Yu-Tong Liu, Su-Ying Cui, Yong-He Zhang
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’achat d’article à l’unité est indisponible à l’heure actuelle.
Déjà abonné à cette revue ?