Mesenchymal stem cell-associated lncRNA in osteogenic differentiation - 09/06/19

Doi : 10.1016/j.biopha.2019.108912

Cheng Ju ^a,^b,^c,^d,^{^{1
These authors contributed equally to this work.}} , Renfeng Liu ^a,^b,^c,^d,^{^{1
These authors contributed equally to this work.}} , Yuan-Wei Zhang ^d,^{^{1
These authors contributed equally to this work.}} , Yu Zhang ^b,^c , Ruihao Zhou ^a , Jun Sun ^a , Xiao-Bin Lv ^a,^⁎ , Zhiping Zhang ^a,^b,^c,^⁎
^a Jiangxi Key Laboratory of Cancer Metastasis and Precision Treatment, The Third Affiliated Hospital of Nanchang University, Nanchang, China
^b Department of Orthopedics, The Third Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330008, China
^c Nanchang Key Laboratory of Orthopaedics, The Third Affiliated Hospital of Nanchang University, Nanchang, China
^d Medical Department of Graduate School, Nanchang University, Nanchang, Jiangxi 330006, China

^⁎Corresponding author at: Department of Orthopedics, The Third Affiliated Hospital of Nanchang University, Nanchang, 128 Xiangshan Northern Road, Nanchang, Jiangxi 330008, China.Department of OrthopedicsThe Third Affiliated Hospital of Nanchang University, Nanchang128 Xiangshan Northern RoadNanchangJiangxi330008China^⁎⁎Corresponding author at: Jiangxi Key Laboratory of Cancer Metastasis and Precision Treatment, The Third Affiliated Hospital of Nanchang University, 128 Xiangshan Northern Road, Nanchang, Jiangxi 330008, China.Jiangxi Key Laboratory of Cancer Metastasis and Precision TreatmentThe Third Affiliated Hospital of Nanchang University128 Xiangshan Northern RoadNanchangJiangxi330008China

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Abstract

Mesenchymal stem cells (MSCs) have the ability to differentiate into multiple cell types, including osteogenic, chondrogenic and adipogenic lineages. Osteogenic differentiation of MSCs plays a critical role in bone tissue engineering. Inducing MSC osteogenesis represents a potential treatment that promotes bone formation and bone regeneration. Recently, long non-coding RNA (lncRNA) was shown to participate in the occurrence and development of various diseases. Different lncRNA expression patterns can regulate the cell cycle, proliferation, metastasis, immunobiology and differentiation. With the recent extensive study of lncRNAs, an increasing number of lncRNAs are being studied in the MSC field. Furthermore, some lncRNAs have been confirmed to regulate MSC osteogenesis. Therefore, here, we review research concerning lncRNA in osteogenic differentiation of MSCs and highlight the importance of lncRNA in bone formation and bone regeneration.

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Keywords : MSCs, Osteogenic differentiation, lncRNA, Bone formation and bone regeneration, Bone tissue engineering

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Vol 115

Article 108912- juillet 2019 Retour au numéro

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Mesenchymal stem cell-associated lncRNA in osteogenic differentiation - 09/06/19

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