Therapeutic effects of curcumin and ursodexycholic acid on non-alcoholic fatty liver disease - 09/06/19
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Graphical abstract |
Highlights |
• | Non-alcoholic fatty liver disease is characterized by mitochondrial dysfunction, oxidative stress and inflammatory response. |
• | Curcumin and Ursodeoxycholic acid due to their anti-inflammatory and therapeutic properties in liver injuries. |
• | Treatment of rats with curcumin and ursodecycholic acid, induced with NAFLD, reduces apoptosis, inflammatory response and oxidative stress. |
• | Combinational therapy has superior outcomes, as compared to solo treatment. |
Abstract |
Fatty liver disease is commonly associated with inflammation, oxidative stress and apoptosis of hepatocytes. This study was designed to investigate the combinational therapeutic effects of curcumin (CMN) and Ursodeoxycholic acid (UDCA) on non-alcoholic fatty liver disease (NAFLD). Male Wistar rats were divided into 8 groups: NAFLD-induced rats, NAFLD-induced rats + CMN, NAFLD-induced rats + UDCA, and NAFLD-induced rats that received CMN + UDCA. CMN (200 mg/kg) and UDCA (80 mg/kg) was administered orally for 14 and 28 consecutive days. Biochemical and histopathological analysis were conducted in all the groups. It was seen that co-administration of CMN and UDCA significantly reduced fatty degeneration, cellular necrosis, edema, and immune cell infiltration compared to non-treated NAFLD-induced rats. Whereas, combinational therapy caused a significant decrease in levels of SGOT and SGPT enzymes and expression of p53, caspase III, iNOS and bcl-2 mRNA and proteins, in variant with the treatment of CMN and UDCA, respectively. Co-administration of CMN and UDCA was also associated with the restoration of the levels of serum TG and HDL-C however, had no effect on LDL-C. It also resulted in an in TAC, GSH- PX, and SOD and decrease in MDA level. Our study concludes that combinational therapy of CMN and UDCA is effective for the treatment of NAFLD, as compared to their solo treatment.
Le texte complet de cet article est disponible en PDF.Keywords : Curcumin, Ursodexycholic acid, NAFLD, Fatty liver
Plan
Vol 115
Article 108938- juillet 2019 Retour au numéro
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