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Fine particulate matter exposure during pregnancy and infancy and incident asthma - 06/06/19

Doi : 10.1016/j.jaci.2019.03.024 
Chau-Ren Jung, PhD a, b, Wei-Ting Chen, PhD c, Yu-Hsin Tang, MSc a, Bing-Fang Hwang, PhD a, d,
a Department of Occupational Safety and Health, College of Public Health, China Medical University, Taichung, Taiwan 
b Japan Environment and Children's Study Programme Office, National Institute for Environmental Studies, Tsukuba, Japan 
c Department of Atmospheric Sciences, National Taiwan University, Taipei, Taiwan 
d Department of Occupational Therapy, College of Medical and Health Science, Asia University, Taichung, Taiwan 

Corresponding author: Bing-Fang Hwang, PhD, Department of Occupational Safety and Health, China Medical University, No 91 Hsueh-Shih Rd, Taichung 40402, Taiwan.Department of Occupational Safety and HealthChina Medical UniversityNo 91 Hsueh-Shih RdTaichung40402Taiwan

Abstract

Background

Lung development is a multistage process from conception to the postnatal period, disruption of which by air pollutants can trigger later respiratory morbidity.

Objective

We sought to evaluate the effects of weekly average fine particulate matter (particulate matter with an aerodynamic diameter less than 2.5 μm [PM2.5]) exposure during pregnancy and infancy on asthma and identify vulnerable times to help elucidate possible mechanisms of the effects of PM2.5 on asthma symptoms.

Methods

A birth cohort study including 184,604 children born during 2004-2011 in Taichung City was retrieved from the Taiwan Maternal and Child Health Database and followed until 2014. A daily satellite-based hybrid model was applied to estimate PM2.5 exposure for each subject. A Cox proportional hazard model combined with a distributed lag nonlinear model was used to evaluate the associations of asthma with PM2.5 exposure during pregnancy and infancy.

Results

The birth cohort contained 34,336 asthmatic patients, and the mean age of children given a diagnosis of asthma was 3.39 ± 1.78 years. Increased exposure to PM2.5 during gestational weeks 6 to 22 and 9 to 46 weeks after birth were significantly associated with an increased incidence of asthma. The exposure-response relationship indicated that the hazard ratio (HR) of asthma increased steeply at PM2.5 exposure of greater than 93 μg/m3 during pregnancy. Additionally, the HRs remained significant with postnatal exposure to PM2.5 between 26 and 72 μg/m3 (range, 1.01-1.07 μg/m3), followed by a sharp increase in HRs at PM2.5 exposure of greater than 73 μg/m3.

Conclusion

Both prenatal and postnatal exposures to PM2.5 were associated with later development of asthma. The vulnerable time windows might be within early gestation and midgestation and infancy.

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Graphical abstract




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Key words : Asthma, air pollution, birth cohort, particulate matter with an aerodynamic diameter less than 2.5 μm, prenatal, postnatal, vulnerable time windows

Abbreviations used : AOD, Cox PH model, DLNM, HR, MODIS, NHIRD, OR, PM, PM2.5, PM10, SES, TBR, TMCHD


Plan


 Supported by China Medical University (CMU107-Z-04), Taichung, Taiwan, and the Ministry of Science and Technology (MOST 105-2119-M-039-002, MOST 106-2119-M-039-001, MOST 107-2119-M-039-001, and MOST 106-2811-M-039-002), Taipei, Taiwan.
 Disclosure of potential conflict of interest: The authors declare that they have no relevant conflicts of interest.


© 2019  American Academy of Allergy, Asthma & Immunology. Publié par Elsevier Masson SAS. Tous droits réservés.
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Vol 143 - N° 6

P. 2254 - juin 2019 Retour au numéro
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