Infant Psychosocial Environment Predicts Adolescent Cardiometabolic Risk: A Prospective Study - 23/05/19
Abstract |
Objective |
To prospectively assess whether the infant psychosocial environment was associated with cardiometabolic risk as early as adolescence.
Study design |
Participants were recruited in Santiago, Chile, and have been followed from infancy. Inclusion criteria included healthy infants with birth weight ≥3 kg and a stable caregiver. The psychosocial environment, including depressive symptoms, stressful life events, poor support for child development, father absence, and socioeconomic status, was reported by mothers at 6-12 months. Body mass index (BMI) z score was assessed at 5 and 10 years. BMI z score, waist-to-hip ratio, systolic and diastolic blood pressure, fat mass and body fat percentage, fasting glucose, total and high-density lipoprotein cholesterol, and homeostatic model of insulin resistance were tested in adolescence.
Results |
Adolescents ranged from 16 to 18 years of age (n = 588; 48.1% female). A poorer infant psychosocial environment was associated with BMI z score at 10 years (β = 0.10, 95% CI = 0.00-0.19) and in adolescence (β = 0.15, 95% CI = 0.06-0.24) but not at 5 years. A poorer infant psychosocial environment was associated with higher blood pressure (β = 0.15, 95% CI = 0.05-0.24), greater anthropometric risk (β = 0.13, 95% CI = 0.03-0.22), greater biomarker (triglycerides, homeostatic model assessment of insulin resistance, total cholesterol) risk (β = 0.12, 95% CI = 0.02-0.22), and a higher likelihood of metabolic syndrome in adolescence (aOR = 1.50; 95% CI = 1.06-2.12).
Conclusions |
These findings demonstrate that a poorer infant psychosocial environment was associated with greater adolescent cardiometabolic risk. The results support screening for infants’ psychosocial environments and further research into causality, mechanisms, prevention, and intervention.
Le texte complet de cet article est disponible en PDF.Keywords : infancy, cardiometabolic risk, adolescence, BMI, blood pressure, metabolic syndrome, stress
Abbreviations : ACE, BMI, CVD, HOMA-IR, M, MetS, WHO
Plan
Funded by the National Institutes of Health (F32HD088029 [to J.D.], R01HD14122 [to B.L.], R01HD33487 [to B.L. and S.G.], and R01HL088530 [to S.G.]). The funder had no role in the study design; the collection, analysis, and interpretation of data; the writing of the report; or the decision to submit the manuscript for publication. The authors declare no conflicts of interest. |
Vol 209
P. 85 - juin 2019 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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