Benefits of Physical Activity for Depression and Fatigue in Multiple Sclerosis: A Longitudinal Analysis - 23/05/19
Abstract |
Objectives |
To examine the longitudinal relationship between physical activity and fatigue and depression among youth with demyelinating conditions.
Study design |
From September 2013 to March 2017, we performed a longitudinal study of consecutive youth diagnosed at their first visit with pediatric onset multiple sclerosis (POMS) or monophasic acquired demyelinating syndromes (mono-ADS) at a neuroinflammatory disorders clinic in a tertiary children's hospital. Fatigue was determined at each visit by the Pediatric Quality of Life Multidimensional Fatigue Scale, depressive symptoms by the Center of Epidemiologic Studies Depression Children Rating Scale, and physical activity level by the Godin Leisure Time Exercise Questionnaire. Mixed linear models were used to examine the associations of moderate-to-vigorous physical activity (MVPA) with fatigue and depression over time, adjusting for age, time from incident demyelination, sex, number of relapses, relapse within 30 days, and disability.
Results |
In 182 patients (48 POMS, age 15 ± 1.7 years, 35 female; and 134 mono-ADS, age 12 ± 3.6 years 67 female) with 538 visits (mean follow-up 3.6 ± 2.7 years and 4.2 ± 3.3 years, respectively), a trajectory of increased fatigue over time was observed in POMS (2.28 points/year, P = .008) and mono-ADS (1.33 points/year, P = .007) patients. Youth with POMS had more depressive symptoms (estimate = 11.4 points, P < .002) than mono-ADS. Depressive symptoms increased over time in female patients with POMS (estimate = 1.4 points/year, P < .02). MVPA was associated with lower depression (−0.09, P < .001) and general fatigue (0.13, P = .02) over time in POMS.
Conclusions |
Youth with POMS who have higher levels of MVPA demonstrate lesser depressive symptoms and lower fatigue over time. Our results may inform future interventions to manage mood and fatigue in POMS.
Le texte complet de cet article est disponible en PDF.Keywords : exercise, pediatric, multiple sclerosis, psychosocial outcomes
Abbreviations : EDSS, Mono-ADS, MS, MVPA, PedsQL-MFS, POMS
Plan
| Supported by Multiple Sclerosis Society of Canada (EGID 2736 [to S.S.]), The Hospital for Sick Children Foundation, SickKids Research Institute, Mario Batali Foundation/National Multiple Sclerosis Society (PP 2256 [to E.Y.]), National Multiple Sclerosis Society (MB 0031 [to E.Y.]), and Centre of Brain and Mental Health at the Hospital for Sick Children. M.F. has received research funds from NMSS, CMSC, MSSC, and PCORI. R.M. has received research funds from NMSS, CMSC, NIH, and PCORI. E.Y. has received funds from NMSS, CIHI, CIHR, OIRM, SCN, CBMH, MS Society of Canada, Mario Batali Foundation, PCORI, SickKids Foundation, CBMH Innovation Fund, CMSC, Rare Disease Foundation, Biogen MA Inc., and The Guthy Jackson Charitable Foundation; serves as a relapse adjudicator for ACI; served on a scientific advisory panel for Juno Therapeutics; received a speaker's honorarium from Novartis; and received unrestricted funds from Teva for an educational symposium. The other authors declare no conflicts of interest. |
Vol 209
P. 226 - juin 2019 Retour au numéro
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