Midazolam: Safety of use in palliative care : A systematic critical review - 17/05/19
, Krzysztof Szymański c, Mary-Tiffany Oduah d, Katarzyna Stachowiak-Szymczak e, Jacek Łuczak f, Maciej Sopata fBienvenue sur EM-consulte, la référence des professionnels de santé.
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Abstract |
Purpose |
The undesired effects of midazolam can be life-threatening. This paper delineates the findings related to the pharmacokinetics, adverse effects and drug-drug interactions as well as associated therapeutic implications for safe midazolam use.
Methods |
A systematic review of literature was conducted.
Results |
The pharmacokinetics of midazolam depends on hepatic and renal functions, fat tissue mass, route and duration of administration, as well as potential drug-drug interactions. Palliative care patients constitute a high-risk group prone to side effects of drugs, due to polytherapy and multi-organ failure.
Conclusion |
Midazolam is one of three most frequently administered drugs in palliative care. The indications for its use include anxiety, dyspnea, seizures, vomiting refractory to treatment, agitation, myoclonus, status epilepticus, restlessness, delirium, pruritus, hiccups, insomnia, analgosedation, palliative sedation and preventing or counteracting undesired effects of ketamine.
Le texte complet de cet article est disponible en PDF.Keywords : Midazolam, Drug-drug interactions, Palliative care, Pharmacokinetics, Palliative sedation, Context-sensitive half-life
Plan
Vol 114
Article 108838- juin 2019 Retour au numéro
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