Burden of hospital admissions caused by respiratory syncytial virus (RSV) in infants in England: A data linkage modelling study - 11/05/19
Highlights |
• | Novel methodology using linked data to estimate the hospital burden of RSV. |
• | Detailed estimates of RSV-associated admissions and bed days in infants in England. |
• | RSV-associated admissions peaked in infants aged 6 weeks. |
• | RSV-associated admissions peaked in infants born September to November. |
Summary |
Objectives |
Current national estimates of respiratory syncytial virus (RSV)-associated hospital admissions are insufficiently detailed to determine optimal vaccination strategies for RSV. We employ novel methodology to estimate the burden of RSV-associated hospital admissions in infants in England, with detailed stratification by patient and clinical characteristics.
Methods |
We used linked, routinely collected laboratory and hospital data to identify laboratory-confirmed RSV-positive and RSV-negative respiratory hospital admissions in infants in England, then generate a predictive logistic regression model for RSV-associated admissions. We applied this model to all respiratory hospital admissions in infants in England, to estimate the national burden of RSV-associated admissions by calendar week, age in weeks and months, clinical risk group and birth month.
Results |
We estimated an annual average of 20,359 (95% CI 19,236-22,028) RSV-associated admissions in infants in England from mid-2010 to mid-2012. These admissions accounted for 57,907 (95% CI 55,391-61,637) annual bed days. 55% of RSV-associated bed days and 45% of RSV-associated admissions were in infants <3 months old. RSV-associated admissions peaked in infants aged 6 weeks, and those born September to November.
Conclusions |
We employed novel methodology using linked datasets to produce detailed estimates of RSV-associated admissions in infants. Our results provide essential baseline epidemiological data to inform future vaccine policy.
Le texte complet de cet article est disponible en PDF.Keywords : Respiratory syncytial virus, RSV, Data linkage, Respiratory tract infection, Bronchiolitis, Pneumonia, Hospital admissions, Infants
Plan
Vol 78 - N° 6
P. 468-475 - juin 2019 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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