Clinical and Physiologic Implications of Negative Cardiopulmonary Interactions in Coexisting Chronic Obstructive Pulmonary Disease-Heart Failure - 09/05/19
, Alcides Rocha, MD, PhD b, Danilo C. Berton, MD, PhD c, Denis E. O’Donnell, MD, FRCPI, FRCPC, FERS dRésumé |
Chronic obstructive pulmonary disease (COPD) and heart failure with reduced ejection fraction (HF) frequently coexist in the elderly. Expiratory flow limitation and lung hyperinflation due to COPD may adversely affect central hemodynamics in HF. Low lung compliance, increased alveolar-capillary membrane thickness, and abnormalities in pulmonary perfusion because of HF further deteriorates lung function in COPD. We discuss how those negative cardiopulmonary interactions create challenges in clinical interpretation of pulmonary function and cardiopulmonary exercise tests in coexisting COPD-HF. In the light of physiologic concepts, we also discuss the influence of COPD or HF on the current medical treatment of each disease.
Le texte complet de cet article est disponible en PDF.Keywords : Lung function, Cardiopulmonary interactions, Cardiopulmonary exercise testing, Dyspnea, Chronic obstructive pulmonary disease
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| Disclosure Statement: No author has any relationship with a commercial company that has a direct financial interest in subject matter or materials discussed in article or with a company making a competing product. |
Vol 40 - N° 2
P. 421-438 - juin 2019 Retour au numéro
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