Identification of two new core chromosome-encoded superantigens in Streptococcus pyogenes; speQ and speR - 19/04/19
Highlights |
• | Superantigens contribute to disease caused by Streptococcus pyogenes. |
• | Two new superantigen genes, speQ and speR, have been identified. |
• | SPEQ and SPER were capable of inducing T cell proliferation. |
• | speQ/R were found in certain genotypes after testing >4000 S. pyogenes genomes. |
• | There are now 16 streptococcal superantigens with 14 detected in S. pyogenes. |
Summary |
Superantigens are ubiquitous within the Streptococcus pyogenes genome, which suggests that superantigen-mediated T-cell activation provides a significant selective advantage. S. pyogenes can carry a variable complement of the 11 known superantigens. We have identified two novel S. pyogenes superantigens, denoted speQ and speR, adjacent to each other in the core-chromosome of isolates belonging to eleven different emm-types. Although distinct from other superantigens, speQ and speR were most closely related to speK and speJ, respectively. Recombinant SPEQ and SPER were mitogenic towards human peripheral blood mononuclear cells at ng/ml concentrations, and SPER was found to be more mitogenic than SPEQ.
Le texte complet de cet article est disponible en PDF.Keywords : Streptococcus pyogenes, Group A Streptococcus, Superantigens, Scarlet fever, Toxic shock syndrome, Mitogen
Plan
Vol 78 - N° 5
P. 358-363 - mai 2019 Retour au numéro
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