Amputation results in a wide range of functional limitations; advances in surgical, rehabilitative, and prosthetic care are aimed at optimizing functional quality of life for the spectrum of individuals with limb loss. This article initially focuses on advances in surgical and rehabilitative care, followed by noteworthy advances in prosthetics, including potential advantages and disadvantages. Although prosthetics tend to dominate attention in the field, it is important to remember that optimizing surgical and rehabilitative care are vital components of enhancing functional recovery and quality of life in people with limb loss.