Evaluation of neutron dosimetry on pancreatic cancer phantom model for application of intraoperative boron neutron-capture therapy - 22/03/08
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Abstract |
Pancreatic cancer is one of the most difficult neoplasms to cure and there is a need for new combinated therapy. If sufficient boron compound can be targeted accurate to the tumour, Boron Neutron-Capture Therapy (BNCT) can be applied to pancreatic cancer. We administrated BNCT to a cancer with pancreatic cancer patient using intraoperative irradiation. In this study, we performed preliminary dosimetry of a phantom model of the abdominal cavity. The flux of 8>×107n/cm2/s (0.1 ratio) was 4.5cm in depth from the surface in the case of simple irradiation, and the field of thermal neutrons was spread as 13cm and 11.5cm were usage of Void and Void with LiF collimation, respectively in thermal (OO-0011) mode. In the case of epithermal (CO-0000) mode, epithermal and fast components are four times higher at the surface level. In the case of mixed beam (OO-0000) mode, thermal neutron flux was the same as thermal neutron mode at a depth of 10cm, but the gamma-ray component was two times higher than that of thermal neutron mode. With the use of Void and LiF collimation, thermal neutrons were selectively applied to the tumour combined with the CT-imaging of the cancer patient. This means that we could irradiate the tumour selectively and safely as possible, reducing the effects on neighboring healthy tissues. High resolution whole body dosimetry will be necessary to extend the application of BNCT to pancreatic cancer.
Le texte complet de cet article est disponible en PDF.Keywords : Boron Neutron-Capture Therapy (BNCT), Pancreatic cancer, Intraoperative BNCT, Thermal neutron, Void, LiF collimation
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Vol 61 - N° 8
P. 505-514 - septembre 2007 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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