Trypanocidal activity of arsonoliposomes: Effect of vesicle lipid composition - 22/03/08
Corresponding author. Laboratory of Pharmaceutical Technology, Department of Pharmacy, University of Patras, Rio 26500, Greece. Tel.: +30 2610 969 332; fax: +30 2610 996 302.Bienvenue sur EM-consulte, la référence des professionnels de santé.
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Abstract |
Sonicated arsonoliposomes were prepared using an arsonolipid with palmitic acid acyl chain (C16), mixed with phosphatidylcholine (PC-based) or 1,2-distearoyl-sn-glycero-3-phosphocholine (DSPC-based), and cholesterol (Chol) with a molar ratio C16 /PC or DSPC/ Chol 8:12:10. PEG-lipid (1,2-distearoyl-sn-glycero-3-phosphoethanolamine conjugated to polyethylenoglycol 2000) containing vesicles (pegylated-arsonoliposomes) were also prepared. The in vitro and in vivo trypanocidal activity of the various types of arsonoliposomes was evaluated.
Although PC-based arsonoliposomes exhibited in vivo activity on an acute trypanosomiasis animal model, no evidence of activity was demonstrated for DSPC-based or pegylated-arsonoliposomes on a chronic model. Despite the fact that DSPC-based and pegylated-arsonoliposomes have better bioavailability compared to PC-based ones, their in vitro activity is lower than that of PC-based arsonoliposomes, indicating the importance of arsonoliposome lipid composition on their trypanocidal activity and suggesting that further arsonoliposome structure design is required to overcome these disadvantages.
Le texte complet de cet article est disponible en PDF.Keywords : Liposome, Arsonolipid, Arsenic, In vivo, Trypanocidal activity, Trypanosoma, Toxicity, Arsonoliposome
Plan
Vol 61 - N° 8
P. 499-504 - septembre 2007 Retour au numéro
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