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Allergic Rhinitis and its Impact on Asthma (ARIA) Phase 4 (2018): Change management in allergic rhinitis and asthma multimorbidity using mobile technology - 06/03/19

Doi : 10.1016/j.jaci.2018.08.049 
Jean Bousquet, MD a, b, c, , Peter W. Hellings, MD d, Ioana Agache, MD e, Flore Amat, MD rr, Isabella Annesi-Maesano, MD f, Ignacio J. Ansotegui, MD g, Josep M. Anto, PhD h, i, j, k, Claus Bachert, MD l, Eric D. Bateman, MD m, Anna Bedbrook, BSc b, Kazi Bennoor, MD n, Mickael Bewick, MD o, Carsten Bindslev-Jensen, MD p, Sinthia Bosnic-Anticevich, PhD q, Isabelle Bosse, MD r, Jan Brozek, MD s, Luisa Brussino, MD t, Giorgio W. Canonica, MD u, Victoria Cardona, MD v, Thomas Casale, MD w, Alfonso M. Cepeda Sarabia, MD x, Niels H. Chavannes, MD y, Lorenzo Cecchi, MD z, Jaime Correia de Sousa, MD aa, Elisio Costa, PhD bb, Alvaro A. Cruz, MD cc, Wienczyslawa Czarlewski, MD dd, Giuseppe De Carlo, MD ee, Giulia De Feo, MD ff, Pascal Demoly, MD f, gg, Philippe Devillier, MD hh, Mark S. Dykewicz, MD ii, Yehia El-Gamal, MD jj, Esben E. Eller, MD p, Joao A. Fonseca, MD kk, Jean-François Fontaine, MD ll, Wytske J. Fokkens, MD mm, Maria-Antonieta Guzmán, MD nn, Tari Haahtela, MD oo, Maddalena Illario, MD pp, Juan-Carlos Ivancevich, MD qq, Jocelyne Just, MD rr, Igor Kaidashev, MD ss, Musa Khaitov, PhD tt, Omer Kalayci, MD uu, Thomas Keil, MD vv, Ludger Klimek, MD ww, Marek L. Kowalski, MD xx, Piotr Kuna, MD yy, Violeta Kvedariene, MD zz, Desiree Larenas-Linnemann, MD aaa, Daniel Laune, PhD bbb, Lan T.T. Le, MD ccc, Karin Lodrup Carlsen, MD ddd, Olga Lourenço, PhD eee, Bassam Mahboub, MD fff, Alpana Mair, PhD ggg, Enrica Menditto, PhD hhh, Branislava Milenkovic, MD iii, Mario Morais-Almeida, MD jjj, Ralph Mösges, MD kkk, Joaquim Mullol, MD lll, Ruth Murray, PhD mmm, Robert Naclerio, MD nnn, Leyla Namazova-Baranova, MD ooo, Ettore Novellino, PhD ppp, Robyn E. O'Hehir, MD qqq, Ken Ohta, MD rrr, Yoshitaka Okamoto, MD sss, Kimi Okubo, MD ttt, Gabrielle L. Onorato, MSc b, Susanna Palkonen, MD ee, Petr Panzner, MD uuu, Nikos G. Papadopoulos, MD vvv, Hae-Sim Park, MD www, Ema Paulino, PhD xxx, Ruby Pawankar, MD yyy, Oliver Pfaar, MD zzz, aaaa, Davor Plavec, MD bbbb, Ted A. Popov, MD cccc, Paul Potter, MD dddd, Emmanuel P. Prokopakis, MD eeee, Menachem Rottem, MD ffff, Dermot Ryan, MD gggg, Johanna Salimäki, MSc hhhh, Boleslaw Samolinski, MD iiii, Mario Sanchez-Borges, MD jjjj, Holger J. Schunemann, MD s, Aziz Sheikh, MD kkkk, Juan-Carlos Sisul, MD llll, Rojin Rajabian-Söderlund, PhD mmmm, Talant Sooronbaev, MD nnnn, Cristiana Stellato, MD ff, Teresa To, PhD oooo, Ana-Maria Todo-Bom, MD pppp, Peter-Valentin Tomazic, MD qqqq, Sanna Toppila-Salmi, MD oo, Antonio Valero, MD rrrr, Arunas Valiulis, MD ssss, Erkka Valovirta, MD tttt, Maria-Teresa Ventura, MD uuuu, Martin Wagenmann, MD vvvv, De Yun Wang, MD wwww, Dana Wallace, MD xxxx, Susan Waserman, MD yyyy, Magnus Wickman, MD zzzz, Arzu Yorgancioglu, MD aaaaa, Luo Zhang, MD bbbbb, Nanshan Zhong, MD ccccc, Mihaela Zidarn, MD ddddd, Torsten Zuberbier, MD eeeee
for the

Mobile Airways Sentinel Network (MASK) Study Group

  For a listing of members of the Mobile Airways Sentinel Network (MASK) Study Group, see the acknowledgments section at the end of the article.
J. Bousquet, P.W. Hellings, W. Aberer, I. Agache, C.A. Akdis, M. Akdis, M.R. Alberti, R. Almeida, F. Amat, R. Angles, I. Annesi-Maesano, I.J. Ansotegui, J.M. Anto, S. Arnavielle, E. Asayag, A. Asarnoj, H. Arshad, F. Avolio, E. Bacci, C. Bachert, I. Baiardini, C. Barbara, M. Barbagallo, I. Baroni, B.A. Barreto, X. Basagana, E.D. Bateman, M. Bedolla-Barajas, A. Bedbrook, M. Bewick, B. Beghé, E.H. Bel, K.C. Bergmann, K.S. Bennoor, M. Benson, L. Bertorello, A.Z. Białoszewski, T. Bieber, S. Bialek, C. Bindslev-Jensen, L. Bjermer, H. Blain, F. Blasi, A. Blua, M. Bochenska Marciniak, I. Bogus-Buczynska, A.L. Boner, M. Bonini, S. Bonini, C.S. Bosnic-Anticevich, I. Bosse, J. Bouchard, L.P. Boulet, R. Bourret, P.J. Bousquet, F. Braido, V. Briedis, C.E. Brightling, J. Brozek, C. Bucca, R. Buhl, R. Buonaiuto, C. Panaitescu, M.T. Burguete Cabañas, E. Burte, A. Bush, F. Caballero-Fonseca, D. Caillot, D. Caimmi, M.A. Calderon, P.A.M. Camargos, T. Camuzat, G. Canfora, G.W. Canonica, V. Cardona, K.H. Carlsen, P. Carreiro-Martins, A.M. Carriazo, W. Carr, C. Cartier, T. Casale, G. Castellano, L. Cecchi, A.M. Cepeda Sarabia, N.H. Chavannes, Y. Chen, R. Chiron, T. Chivato, E. Chkhartishvili, A.G. Chuchalin, K.F. Chung, M.M. Ciaravolo, A. Ciceran, C. Cingi, G. Ciprandi, A.C. Carvalho Coehlo, L. Colas, E. Colgan, J. Coll, D. Conforti, J. Correia de Sousa, R.M. Cortés-Grimaldo, F. Corti, E. Costa, M.C. Costa-Dominguez, A.L. Courbis, L. Cox, M. Crescenzo, A.A. Cruz, A. Custovic, W. Czarlewski, S.E. Dahlen, C. Dario, J. da Silva, Y. Dauvilliers, U. Darsow, F. De Blay, G. De Carlo, T. Dedeu, M. de Fátima Emerson, G. De Feo, G. De Vries, B. De Martino, N. de Paula Motta Rubini, D. Deleanu, P. Demoly, J.A. Denburg, P. Devillier, S. Di Capua Ercolano, N. Di Carluccio, A. Didier, D. Dokic, M.G. Dominguez-Silva, H. Douagui, G. Dray, R. Dubakiene, S.R. Durham, G. Du Toit, M.S. Dykewicz, Y. El-Gamal, P. Eklund, E. Eller, R. Emuzyte, J. Farrell, A. Farsi, J. Ferreira de Mello, J. Ferrero, A. Fink-Wagner, A. Fiocchi, W.J. Fokkens, J.A. Fonseca, J.F. Fontaine, S. Forti, J.M. Fuentes-Perez, J.L. Gálvez-Romero, A. Gamkrelidze, J. Garcia-Aymerich, C.Y. García-Cobas, M.H. Garcia-Cruz, B. Gemicioğlu, S. Genova, C. George, J.E. Gereda, R. Gerth van Wijk, R.M. Gomez, J. Gómez-Vera, S. González Diaz, M. Gotua, I. Grisle, M. Guidacci, N.A. Guldemond, Z. Gutter, M.A. Guzmán, T. Haahtela, J. Hajjam, L. Hernández, J.O.'B. Hourihane, Y.R. Huerta-Villalobos, M. Humbert, G. Iaccarino, M. Illario, J.C. Ivancevich, E.J. Jares, E. Jassem, S.L. Johnston, G. Joos, K.S. Jung, M. Jutel, I. Kaidashev, O. Kalayci, A.F. Kalyoncu, J. Karjalainen, P. Kardas, T. Keil, P.K. Keith, M. Khaitov, N. Khaltaev, J. Kleine-Tebbe, L. Klimek, M.L. Kowalski, M. Kuitunen, I. Kull, P. Kuna, M. Kupczyk, V. Kvedariene, E. Krzych-Fałta, P. Lacwik, D. Larenas-Linnemann, D. Laune, D. Lauri, J. Lavrut, L.T.T. Le, M. Lessa, G. Levato, J. Li, P. Lieberman, A. Lipiec, B. Lipworth, K.C. Lodrup Carlsen, R. Louis, O. Lourenço, J.A. Luna-Pech, K. Maciej, A. Magnan, B. Mahboub, D. Maier, A. Mair, I. Majer, J. Malva, E. Mandajieva, P. Manning, E. De Manuel Keenoy, G.D. Marshall, M.R. Masjedi, J.F. Maspero, E. Mathieu-Dupas, J.J. Matta Campos, A.L. Matos, M. Maurer, S. Mavale-Manuel, O. Mayora, M.A. Medina-Avalos, E. Melén, E. Melo-Gomes, E.O. Meltzer, E. Menditto, J. Mercier, N. Miculinic, F. Mihaltan, B. Milenkovic, G. Moda, M.D. Mogica-Martinez, Y. Mohammad, I. Momas, S. Montefort, R. Monti, D. Mora Bogado, M. Morais-Almeida, F.F. Morato-Castro, R. Mösges, A. Mota-Pinto, P. Moura Santo, J. Mullol, L. Münter, A. Muraro, R. Murray, R. Naclerio, R. Nadif, M. Nalin, L. Napoli, L. Namazova-Baranova, H. Neffen, V. Niedeberger, K. Nekam, A. Neou, A. Nieto, L. Nogueira-Silva, M. Nogues, E. Novellino, T.D. Nyembue, R.E. O'Hehir, C. Odzhakova, K. Ohta, Y. Okamoto, K. Okubo, G.L. Onorato, M. Ortega Cisneros, S. Ouedraogo, I. Pali-Schöll, S. Palkonen, P. Panzner, N.G. Papadopoulos, H.S. Park, A. Papi, G. Passalacqua, E. Paulino, R. Pawankar, S. Pedersen, J.L. Pépin, A.M. Pereira, M. Persico, O. Pfaar, J. Phillips, R. Picard, B. Pigearias, I. Pin, C. Pitsios, D. Plavec, W. Pohl, T.A. Popov, F. Portejoie, P. Potter, A.C. Pozzi, D. Price, E.P. Prokopakis, R. Puy, B. Pugin, R.E. Pulido Ross, M. Przemecka, K.F. Rabe, F. Raciborski, R. Rajabian-Soderlund, S. Reitsma, I. Ribeirinho, J. Rimmer, D. Rivero-Yeverino, J.A. Rizzo, M.C. Rizzo, C. Robalo-Cordeiro, F. Rodenas, X. Rodo, M. Rodriguez Gonzalez, L. Rodriguez-Mañas, C. Rolland, S. Rodrigues Valle, M. Roman Rodriguez, A. Romano, E. Rodriguez-Zagal, G. Rolla, R.E. Roller-Wirnsberger, M. Romano, J. Rosado-Pinto, N. Rosario, M. Rottem, D. Ryan, H. Sagara, J. Salimäki, B. Samolinski, M. Sanchez-Borges, J. Sastre-Dominguez, G.K. Scadding, H.J. Schunemann, N. Scichilone, P. Schmid-Grendelmeier, F.S. Serpa, S. Shamai, A. Sheikh, M. Sierra, F.E.R. Simons, V. Siroux, J.C. Sisul, I. Skrindo, D. Solé, D. Somekh, M. Sondermann, T. Sooronbaev, M. Sova, M. Sorensen, M. Sorlini, O. Spranger, C. Stellato, R. Stelmach, R. Stukas, J. Sunyer, J. Strozek, A. Szylling, J.N. Tebyriçá, M. Thibaudon, T. To, A. Todo-Bom, P.V. Tomazic, S. Toppila-Salmi, U. Trama, M. Triggiani, C. Suppli Ulrik, M. Urrutia-Pereira, R. Valenta, A. Valero, A. Valiulis, E. Valovirta, M. van Eerd, E. van Ganse, M. van Hague, O. Vandenplas, M.T. Ventura, G. Vezzani, T. Vasankari, A. Vatrella, M.T. Verissimo, F. Viart, M. Viegi, D. Vicheva, T. Vontetsianos, M. Wagenmann, S. Walker, D. Wallace, D.Y. Wang, S. Waserman, T. Werfel, M. Westman, M. Wickman, D.M. Williams, S. Williams, N. Wilson, J. Wright, P. Wroczynski, P. Yakovliev, B.P. Yawn, P.K. Yiallouros, A. Yorgancioglu, O.M. Yusuf, H.J. Zar, L. Zhang, N. Zhong, M.E. Zernotti, M. Zidarn, T. Zuberbier, C. Zubrinich, A. Zurkuhlen

a University Hospital, Montpellier, France 
b MACVIA-France, Fondation partenariale FMC VIA-LR, Montpellier, France 
c VIMA, INSERM U 1168, VIMA: Ageing and Chronic Diseases Epidemiological and Public Health Approaches, Villejuif, Université Versailles St-Quentin-en-Yvelines, UMR-S 1168, Montigny-le-Bretonneux, and Euforea, Brussels, Belgium 
d Laboratory of Clinical Immunology, Department of Microbiology and Immunology, KU Leuven, Leuven, Belgium 
e Transylvania University Brasov, Brasov, Romania 
f Epidemiology of Allergic and Respiratory Diseases Department, Institute Pierre Louis of Epidemiology and Public Health, INSERM, and UPMC Sorbonne Université, Medical School Saint Antoine, Paris, France 
g Department of Allergy and Immunology, Hospital Quirón Bizkaia, Erandio, Spain 
h ISGlobal, Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain 
i IMIM (Hospital del Mar Research Institute), Barcelona, Spain 
j CIBER Epidemiología y Salud Pública (CIBERESP), Barcelona, Spain 
k Universitat Pompeu Fabra (UPF), Barcelona, Spain 
l Upper Airways Research Laboratory, ENT Department, Ghent University Hospital, Ghent, Belgium 
m Department of Medicine, University of Cape Town, Cape Town, South Africa 
n Department of Respiratory Medicine, National Institute of Diseases of the Chest and Hospital, Dhaka, Bangladesh 
o iQ4U Consultants, London, United Kingdom 
p Department of Dermatology and Allergy Centre, Odense University Hospital, Odense Research Center for Anaphylaxis (ORCA), Odense, Denmark 
q Woolcock Institute of Medical Research, University of Sydney and Woolcock Emphysema Centre and Local Health District, Glebe, Australia 
r Allergist in private practice, La Rochelle, France 
s Department of Health Research Methods, Evidence, and Impact, Division of Immunology and Allergy, Department of Medicine, McMaster University, Hamilton, Ontario, Canada 
t Department of Medical Sciences, Allergy and Clinical Immunology Unit, University of Torino & Mauriziano Hospital, Torino, Italy 
u Personalized Medicine Clinic Asthma & Allergy, Humanitas University, Humanitas Research Hospital, Rozzano, Milan, Italy 
v Allergy Section, Department of Internal Medicine, Hospital Vall d'Hebron, Barcelona, and ARADyAL Spanish Research Network, Barcelona, Spain 
w Division of Allergy/Immunology, University of South Florida, Tampa, Fla 
x Allergy and Immunology Laboratory, Metropolitan University, Simon Bolivar University, Barranquilla, and SLaai, Sociedad Latinoamericana de Allergia, Asma e Immunologia, Barranquilla, Colombia 
y Department of Public Health and Primary Care, Leiden University Medical Center 
z SOS Allergology and Clinical Immunology, USL Toscana Centro, Prato, Italy 
aa Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, and ICVS/3B's, PT Government Associate Laboratory, Braga/Guimarães, Portugal 
bb UCIBIO, REQUINTE, Faculty of Pharmacy and Competence Center on Active and Healthy Ageing of University of Porto (Porto4Ageing), Porto, Portugal 
cc ProAR–Nucleo de Excelencia em Asma, Federal University of Bahia, Brasil and WHO GARD Planning Group, Salvador, Brazil 
dd Medical Consulting Czarlewski, Levallois, France 
ee European Federation of Allergy and Airways Diseases Patients' Associations, Brussels, Belgium 
ff Department of Medicine, Surgery and Dentistry “Scuola Medica Salernitana”, University of Salerno, Salerno, Italy 
gg Department of Respiratory Diseases, Montpellier University Hospital, Montpellier, France 
hh Laboratoire de Pharmacologie Respiratoire UPRES EA220, Hôpital Foch, Suresnes, Université Versailles Saint-Quentin, Université Paris Saclay, Paris, France 
ii Section of Allergy and Immunology, Saint Louis University School of Medicine, St Louis, Mo 
jj Pediatric Allergy and Immunology Unit, Children's hospital, Ain Shams University, Cairo, Egypt 
kk CINTESIS, Center for research in health technologies and information systems, Faculdade de Medicina da Universidade do Porto, and MEDIDA, Lda, Porto, Portugal 
ll Allergist in private practice, Reims, France 
mm Department of Otorhinolaryngology, Academic Medical Centres, AMC, Amsterdam, The Netherlands 
nn Immunology and Allergy Division, Clinical Hospital, University of Chile, Santiago, Chile 
oo Skin and Allergy Hospital, Helsinki University Hospital and University of Helsinki, Helsinki, Finland 
pp Division for Health Innovation, Campania Region and Federico II University and Hospital Naples (DISMET and R1D Unit) Naples, Naples, Italy 
qq Servicio de Alergia e Immunologia, Clinica Santa Isabel, Buenos Aires, Argentina 
rr Allergology Department, Centre de l'Asthme et des Allergies Hôpital d'Enfants Armand-Trousseau (APHP), and Sorbonne Université, UPMC Univ Paris 06, UMR_S 1136, Institut Pierre Louis d'Epidémiologie et de Santé Publique, Equipe EPAR, Paris, France 
ss Ukrainina Medical Stomatological Academy, Poltava, Ukraine 
tt National Research Center, Institute of Immunology, Federal Medicobiological Agency, Laboratory of Molecular immunology, Moscow, Russian Federation 
uu Pediatric Allergy and Asthma Unit, Hacettepe University School of Medicine, Ankara, Turkey 
vv Institute of Social Medicine, Epidemiology and Health Economics, Charité–Universitätsmedizin Berlin, and the Institute for Clinical Epidemiology and Biometry, University of Wuerzburg, Wuerzburg, Germany 
ww Center for Rhinology and Allergology, Wiesbaden, Germany 
xx Department of Immunology and Allergy, Healthy Ageing Research Center, Medical University of Lodz, Lodz, Poland 
yy Division of Internal Medicine, Asthma and Allergy, Barlicki University Hospital, Medical University of Lodz, Lodz, Poland 
zz Faculty of Medicine, Vilnius University, Vilnius, Lithuania 
aaa Center of Excellence in Asthma and Allergy, Médica Sur Clinical Foundation and Hospital, México City, Mexico 
bbb Kyomed, Montpellier, France 
ccc University of Medicine and Pharmacy, Hochiminh City, Vietnam 
ddd Oslo University Hospital, Department of Paediatrics, Oslo, and the University of Oslo, Faculty of Medicine, Institute of Clinical Medicine, Oslo, Norway 
eee Faculty of Health Sciences and CICS–UBI, Health Sciences Research Centre, University of Beira Interior, Covilhã, Portugal 
fff Department of Pulmonary Medicine, Rashid Hospital, Dubai, United Arab Emirates 
ggg DG for Health & Social Care, Scottish Government, Edinburgh, United Kingdom 
hhh CIRFF, Federico II University, Naples, Italy 
iii Clinic for Pulmonary Diseases, Clinical Center of Serbia, Faculty of Medicine, University of Belgrade, Serbian Association for Asthma and COPD, Belgrade, Serbia 
jjj Allergy Center, CUF Descobertas Hospital, Lisbon, Portugal 
kkk Institute of Medical Statistics, and Computational Biology, Medical Faculty, University of Cologne, and CRI-Clinical Research International, Hamburg, Germany 
lll Rhinology Unit & Smell Clinic, ENT Department, Hospital Clínic; Clinical & Experimental Respiratory Immunoallergy, IDIBAPS, CIBERES, University of Barcelona, Barcelona, Spain 
mmm MedScript, Dundalk, Ireland 
nnn Johns Hopkins School of Medicine, Baltimore, Md 
ooo Scientific Centre of Children's Health under the MoH, Moscow, Russian Federation 
ppp Department of Pharmacy of University of Naples Federico II, Naples, Italy 
qqq OHEHIR. Department of Allergy, Immunology and Respiratory Medicine, Alfred Hospital and Central Clinical School, Monash University, Melbourne, and the Department of Immunology, Monash University, Melbourne, Australia 
rrr National Hospital Organization, Tokyo National Hospital, Tokyo, Japan 
sss Department of Otorhinolaryngology, Chiba University Hospital, Chiba, Japan 
ttt Department of Otolaryngology, Nippon Medical School, Tokyo, Japan 
uuu Department of Immunology and Allergology, Faculty of Medicine in Pilsen, Charles University Prague, Prague, Czech Republic 
vvv Center for Pediatrics and Child Health, Institute of Human Development, Royal Manchester Children's Hospital, University of Manchester, Manchester, and the Allergy Department, 2nd Pediatric Clinic, Athens General Children's Hospital “P&A Kyriakou”, University of Athens, Athens, Greece 
www Department of Allergy and Clinical Immunology, Ajou University School of Medicine, Suwon, South Korea 
xxx Farmacias Holon, Lisbon, Portugal 
yyy Department of Pediatrics, Nippon Medical School, Tokyo, Japan 
zzz Center for Rhinology and Allergology, Wiesbaden, Germany 
aaaa Department of Otorhinolaryngology, Head and Neck Surgery, Universitätsmedizin Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany 
bbbb Children's Hospital Srebrnjak, Zagreb, School of Medicine, University J.J. Strossmayer, Osijek, Croatia 
cccc University Hospital “Sv Ivan Rilski”, Sofia, Bulgaria 
dddd Allergy Diagnostic and Clinical Research Unit, University of Cape Town Lung Institute, Cape Town, South Africa 
eeee Department of Otorhinolaryngology University of Crete School of Medicine, Heraklion, Greece 
ffff Division of Allergy Asthma and Clinical Immunology, Emek Medical Center, Afula, Israel 
gggg Allergy and Respiratory Research Group, University of Edinburgh, Edinburgh, United Kingdom 
hhhh Association of Finnish Pharmacies, Helsinki, Finland 
iiii Department of Prevention of Environmental Hazards and Allergology, Medical University of Warsaw, Warsaw, Poland 
jjjj Allergy and Clinical Immunology Department, Centro Médico-Docente la, Trinidad and Clínica El Avila, Caracas, Venezuela 
kkkk Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, United Kingdom 
llll Sociedad Paraguaya de Alergia Asma e Inmunologı'a, Asuncion 
mmmm Department of Nephrology and Endocrinology, Karolinska University Hospital, Stockholm, Sweden 
nnnn Kyrgyzstan National Centre of Cardiology and Internal medicine, Euro-Asian respiratory Society, Bishkek, Kyrgyzstan 
oooo Sidkkids hospitala and Institute of Health Policy, Management and Evaluation, Toronto, Ontario, Canada 
pppp Imunoalergologia, Centro Hospitalar Universitário de Coimbra and Faculty of Medicine, University of Coimbra, Coimbra, Portugal 
qqqq Department of ENT, Medical University of Graz, Graz, Austria 
rrrr Pneumology and Allergy Department CIBERES and Clinical & Experimental Respiratory Immunoallergy, IDIBAPS, University of Barcelona, Barcelona, Spain 
ssss Vilnius University Institute of Clinical Medicine, Clinic of Children's Diseases, and Institute of Health Sciences, Department of Public Health, Vilnius, Lithuania, and the European Academy of Paediatrics (EAP/UEMS-SP), Brussels, Belgium 
tttt Department of Lung Diseases and Clinical Immunology Allergology, University of Turku and Terveystalo Allergy Clinic, Turku, Finland 
uuuu University of Bari Medical School, Unit of Geriatric Immunoallergology, Bari, Italy 
vvvv Department of Otorhinolaryngology, Universitätsklinikum Düsseldorf, Dusseldorf, Germany 
wwww Department of Otolaryngology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 
xxxx Nova Southeastern University, Fort Lauderdale, Fla 
yyyy Department of Medicine, Clinical Immunology and Allergy, McMaster University, Hamilton, Ontario, Canada 
zzzz Centre for Clinical Research Sörmland, Uppsala University, Eskilstuna, Sweden 
aaaaa Department of Pulmonology, Celal Bayar University, Manisa, Turkey 
bbbbb Department of Otolaryngology–Head and Neck Surgery, Beijing TongRen Hospital and Beijing Institute of Otolaryngology, Beijing, China 
ccccc State Key Laboratory of Respiratory Diseases, Guangzhou Institute of Respiratory Disease, First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China 
ddddd University Clinic of Respiratory and Allergic Diseases, Golnik, Slovenia 
eeeee Comprehensive Allergy Center Charité, Department of Dermatology and Allergy, Charité-Universitätsmedizin Berlin, and Global Allergy and Asthma European Network (GA2LEN), Berlin, Germany 

Corresponding author: Jean Bousquet, MD, CHU Arnaud de Villeneuve, 371 Avenue du Doyen Gaston Giraud, 34295 Montpellier Cedex 5, France.CHU Arnaud de Villeneuve371 Avenue du Doyen Gaston GiraudMontpellier Cedex 534295France

Abstract

Allergic Rhinitis and its Impact on Asthma (ARIA) has evolved from a guideline by using the best approach to integrated care pathways using mobile technology in patients with allergic rhinitis (AR) and asthma multimorbidity. The proposed next phase of ARIA is change management, with the aim of providing an active and healthy life to patients with rhinitis and to those with asthma multimorbidity across the lifecycle irrespective of their sex or socioeconomic status to reduce health and social inequities incurred by the disease. ARIA has followed the 8-step model of Kotter to assess and implement the effect of rhinitis on asthma multimorbidity and to propose multimorbid guidelines. A second change management strategy is proposed by ARIA Phase 4 to increase self-medication and shared decision making in rhinitis and asthma multimorbidity. An innovation of ARIA has been the development and validation of information technology evidence-based tools (Mobile Airways Sentinel Network [MASK]) that can inform patient decisions on the basis of a self-care plan proposed by the health care professional.

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Key words : Change management, rhinitis, asthma, Allergic Rhinitis and Its Impact on Asthma

Abbreviations used : AIRWAYS ICP, AR, ARIA, CM, CM2, DG Santé, GINA, GRADE, ICP, IT, MASK, POLLAR, SDM


Plan


 Supported by the European Innovation Partnership on Active and Healthy Ageing and POLLAR (EIT Health, European Union).
 Disclosure of potential conflict of interest: F. Amat reports grants and personal fees from Novartis and nonfinancial support from Zambon and Stallergenes Greer outside the submitted work. C. Bachert reports personal fees from Uriach and Mylan outside the submitted work. F. de Blay reports grants from Stallergenes Greer; personal fees from Novartis, ALK-Abelló, Mundipharma, AstraZeneca, Boehringer and Teva; and other support from Stallergenes Greer, Novartis, ALK-Abelló, Medapharma, Teva, Boehringer, and AstraZeneca outside the submitted work. S. Bosnic-Anticevich reports personal fees from Teva, Boehringer Ingelheim, Sanofi, AstraZeneca, and GlaxoSmithKline and grants from Teva and Meda outside the submitted work. J. Bousquet reports personal fees and other support from Chiesi, Cipla, Hikma, Menarini, Mundipharma, Mylan, Novartis, Sanofi-Aventis, Takeda, Teva, and Uriach outside the submitted work and support from Kyomed. W. Carr reports other from Regeneron/Sanofi, AstraZeneca, Teva, Glenmark Pharmaceuticals, Boehringer Ingelheim, and Optinose outside the submitted work. J. Correia de Sousa reports other support from Boehringer Ingelheim and Novartis and grants from AstraZeneca outside the submitted work. A. A. Cruz reports grants and personal fees from GlaxoSmithKline; personal fees from Boehringer Ingelheim, AstraZeneca, Novartis, Chiesi, Eurofarma, and Mylan; and personal fees from Merck, Sharp & Dohme, and Sanofi-Aventis outside the submitted work. J. C. Ivancevich reports personal fees from Faes Farma and Sanofi and other support from Lab Casasco outside the submitted work. J. Just reports grants and personal fees from Novartis, personal fees from AstraZeneca, grants and personal fees from ALK-Abelló, and personal fees from Thermo Fisher outside the submitted work. P. Kuna reports personal fees from Adamed, Boehringer Ingelheim, and AstraZeneca and personal fees from Chiesi, FAES, Berlin Chemie, Novartis, Polpharma, and Allergopharma outside the submitted work. V. Kvedariene has received payment for consultancy from GlaxoSmithKline and payment for lectures from Stallergenes Greer and Berlin-CHemie outside the submitted work. D. Larenas-Linnemann reports personal fees from GlaxoSmithKline, AstraZeneca, MEDA, Boehringer Ingelheim, Novartis, Grunenthal, UCB, Amstrong, Siegfried, DBV Technologies, MSD, and Pfizer and grants from Sanofi, AstraZeneca, Novartis, UCB, GlaxoSmithKline, Teva, Chiesi, and Boehringer Ingelheim outside the submitted work. R. Mösges reports personal fees from ALK-Abelló, Allergopharma, Allergy Therapeutics, Friulchem, Hexal, Servier, Klosterfrau, Bayer, FAES, GlaxoSmithKline, MSD, Johnson & Johnson, MEDA, Stada, UCB, and Nuvo; grants from ASIT Biotech, Leti, Optima, BitopAG, Hulka, and Ursapharm; grants and personal fees from Bencard and Stallergenes; personal fees and nonfinancial support from Lofarma and Novartis; and nonfinancial support from Atmos, Roxall, Bionorica, Otonomy, and Ferrero outside the submitted work. R Naclerio reports fees from the advisory boards of Sanofi and Novartis. Y. Okamoto reports personal fees from Shionogi, Torii, GlaxoSmithKline, MSD, Kyowa, and Eizai; grants and personal fees from Kyorin and Tiho; and grants from Yakuruto and Yamada Bee Farm outside the submitted work. N. G. Papadopoulos reports personal fees from Abbvie Novartis, Faes Farma, Biomay, HAL, Nutricia Research, Menarini, Novartis, MEDA, MSD, Omega Pharma, and Danone and grants from Menarini outside the submitted work. J. L. Pépin reports grants from the Air Liquide Foundation, AGIR à dom, AstraZeneca, Fisher & Paykel, Mutualia, Philips, Resmed, and Vitalaire and other support from AGIR à dom, AstraZeneca, Boehringer Ingelheim, Jazz Pharmaceutical, Night Balance, Philips, Resmed, and Sefam outside the submitted work. O. Pfaar reports grants and personal fees from ALK-Abelló, Allergopharma, Stallergenes Greer, HAL Allergy Holding BV/HAL Allergie GmbH, Bencard Allergie GmbH/Allergy Therapeutics, Lofarma, ASIT Biotech Tools SA, Laboratorios LETI/LETI Pharma, Anergis SA, grants from Biomay, Nuvo, Circassia, and Glaxo Smith Kline and personal fees from Novartis Pharma, MEDA Pharma, Mobile Chamber Experts (a GA2LEN Partner), Pohl-Boskamp, and Indoor Biotechnologies outside the submitted work. D. Plavec reports grants and personal fees from GlaxoSmithKline; personal fees from Menarini, Pliva, AbbVie, Novartis, MSD, Chiesi, and Revenio; personal fees and nonfinancial support from Boehringer Ingelheim; and nonfinancial support from Philips outside the submitted work. D. Price reports grants and personal fees from Aerocrine, Almirall, Amgen, Cipla, GlaxoSmithKline, Kyorin, Merck, Mylan, and Skyepharma; grants from AKL Research and Development, the Respiratory Effectiveness Group, the British Lung Foundation, and the UK National Health Service; grants and personal fees from AstraZeneca, Boehringer Ingelheim, Chiesi, Mundipharma, Napp, Novartis, Pfizer, Teva, Theravance, and Zentiva; nonfinancial support from the Efficacy and Mechanism Evaluation Programme and Health Technology Assessment outside the submitted work; and stock/stock options from AKL Research and Development Ltd, which produces phytopharmaceuticals; and he owns 74% of the social enterprise Optimum Patient Care (Australia, Singapore, and United Kingdom) and 74% of Observational and Pragmatic Research Institute (Singapore) outside the submitted work. D. Ryan reports personal fees from MEDA and personal fees from Stallergenes outside the submitted work. R. Stelmach reports grants from the São Paulo Research Foundation and MSD; grants and personal fees from Novartis; grants, personal fees, and nonfinancial support from AstraZeneca and Chiesi; and personal fees and nonfinancial support from Boehringer Ingelheim outside the submitted work. A. Todo-Bom reports grants and personal fees from Novartis, Boehringer Ingelheim, Mundipharma, and GlaxoSmithKline; personal fees from Teva Pharma and AstraZeneca; and grants from Leti outside the submitted work. M. Wagenmann reports personal fees from AstraZeneca, Bionorica SE, HAL Allergy, MEDA Pharma, Stallergenes, Teva, and ALK-Abelló; grants and personal fees from Allergopharma and Sanofi Aventis; grants from Allakos; and grants from Hoffmann-La Roche, GlaxoSmithKline, Otonomy, and Strekin outside the submitted work. S. Waserman reports personnal fees from Merck, GlaxoSmithKline, Novartis, Behring, Shire, Sanofi, Barid Aralez, Mylan Meda, and Pediapharm outside the submitted work. T. Zuberbier reports organizational affiliations with the WHO Initiative Allergic Rhinitis and Its Impact on Asthma (ARIA; committee member), the German Society for Allergy and Clinical Immunology (DGAKI; board membership), the European Centre for Allergy Research Foundation (ECARF; head), Global Allergy and Asthma European Network (GA2LEN; Secretary General), and the Committee on Allergy Diagnosis and Molecular Allergology, World Allergy Organization (WAO; membership) outside the submitted work. The rest of the authors declare that they have no relevant conflicts of interest.


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