The Pros-CAT protocol critical appraisal method uses accepted strategies to identify and summarize best evidence to support patient care through evidence-based analysis that includes assessing the patient; developing a concise clinical question; conducting a literature search to identify pertinent research; critically appraising the identified literature for validity, reliability, and applicability to the patient situation; synthesizing the literature into a meaningful conclusion using an organized method; and applying that synthesis to the patient’s need. The Pros-CAT protocol is applicable for practicing clinicians, dental students, postgraduate students, and residents. The Pros-CAT index compares evidence strength for patient applicability.