This article describes and illustrates the current state of chairside computer-aided design computer-aided manufacturing technologies and materials. It provides a historical background and discusses the different components of the chairside digital workflow: intraoral scanners, design software, milling machines, and sinter furnaces. The material range available for chairside digital dentistry is broad and includes polymethyl methacrylates, composite resins, and a large variety of ceramics. Clinical applications and success rates of the different material groups are summarized and discussed based on the current scientific evidence.