Hexane fraction of Annona muricata (Sour sop) seed ameliorates testosterone-induced benign prostatic hyperplasia in rats - 16/02/19
, Taiwo Dorcas Oladipo a, Olubukola Oyebimpe Akanni a, Olusoji John Abiola bBienvenue sur EM-consulte, la référence des professionnels de santé.
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| pages | 11 |
| Iconographies | 9 |
| Vidéos | 0 |
| Autres | 0 |
Graphical abstract |
Highlights |
• | BPh was induced in castrated rats. |
• | BPh rats had 3.8 and 3.9 folds increases in prostatic and organo-somatic weights. |
• | Activities of prostatic acid and alkaline phosphatases increased in BPh rats. |
• | In BPh, increased oxidative stress, inflammation, iNOS, Bcl2, & androgen were observed. |
• | HFAM or finasteride attenuates prostatic weight and inflammation in BPh. |
Abstract |
Background |
Annona muricata is used in traditional African medicine to manage urinary obstruction. In this study, we hypothesized that hexane fraction of Annona muricata (HFAM) seeds will ameliorate testosterone propionate (Tp)-induced benign prostatic hyperplasia (BPh).
Methods |
Castrated rats were assigned into six groups: non-castrated control, castrated control, castrated rats that received Tp (BPh group), [BPh+HFAM], [BPh+HFAM + finasteride], [BPh + finasteride].
Results |
The BPh rats had 3.8 and 3.9 folds increases in prostatic and organo-somatic weight, while treatment with HFAM alone and [HFAM + finasteride] decreased prostatic weight by 22% and 34%, respectively. BPh increased the activities of serum and prostatic total acid phosphatase by 95% and 121%; and activities of serum and prostatic alkaline phosphatase by 54% and 281%, respectively. Serum and prostatic lipid peroxidation were increased by 44% and 82%, respectively, in BPh rats with a concomitant decrease in prostatic superoxide dismutase by 73%. In BPh rats, serum and prostatic myeloperoxidase increased by 4.0 and 2.0 folds, while serum nitric oxide increased by 2.4 folds, respectively. Strong expression of inducible nitric oxide synthase, Bcl2, beta-catenin, androgen and estrogen receptors were observed in BPh rats. Importantly, treatment with HFAM or finasteride (or combination) attenuated prostatic weight, inflammatory and antioxidant indices in BPh rats.
Conclusion |
HFAM may serve as novel therapeutic agent against BPh.
Le texte complet de cet article est disponible en PDF.Keywords : Annona muricata, Androgen, Hyperplasia, Inflammation, Prostate
Plan
Vol 111
P. 403-413 - mars 2019 Retour au numéro
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