MiR-183-5p is required for non-small cell lung cancer progression by repressing PTEN - 16/02/19
, Yanli Li a, ⁎ Bienvenue sur EM-consulte, la référence des professionnels de santé.
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Graphical abstract |
Highlights |
• | MiR-183-5p is upregulated in NSCLC. |
• | MiR-183-5p promotes cell proliferation, migration and cell cycle of NSCLC. |
• | MiR-183-5p directly targets PTEN. |
• | MiR-183-5p increases tumor growth and metastasis in vivo. |
Abstract |
Lung cancer is the leading cause in all cancer deaths. A low survival rate and high recurrence rate of lung cancer make the endeavor to identify new, more effective therapies a primary goal. MicroRNAs (miRNAs) are regarded as regulators of tumorigenesis and it is known that miR-183-5p is significantly upregulated in non-small cell lung cancer (NSCLC), suggesting it has an oncogenic function in lung cancer. In this study, we found that miR-183-5p could promote lung carcinogenesis by directly targeting phosphatase tensin (PTEN). Further experiments indicated that miR-183-5p could suppress p53 and activate AKT signaling through phosphorylation. Moreover, our data indicated that miR-183-5p promoted tumor metastasis and tumor growth in vivo. Collectively, these results showed that miR-183-5p is required for NSCLC development through the suppressing PTEN, and might be a promising target in the diagnosis and treatment of lung cancer in the future.
Le texte complet de cet article est disponible en PDF.Keywords : miR-183-5p, Non-small cell lung cancer, PTEN, Tumorigenesis
Plan
Vol 111
P. 1103-1111 - mars 2019 Retour au numéro
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