Serum homocysteine, folate, and vitamin B12 levels in patients with vitiligo and their potential roles as disease activity biomarkers: A systematic review and meta-analysis - 11/02/19
Abstract |
Background |
Hyperhomocysteinemia and folate and vitamin B12 deficiencies have been reported in patients with vitiligo. Investigating the role of these conditions might shed light on the pathogenesis of vitiligo.
Objective |
To perform a systematic review and meta-analysis of studies assessing serum homocysteine, folate, and vitamin B12 levels in vitiligo patients.
Methods |
Online databases were searched on May 15, 2018, to identify studies comparing serum homocysteine, folate, and vitamin B12 levels between patients with vitiligo and controls. A random effects model was used.
Results |
Twenty-two studies involving a total of 1448 patients with vitiligo were included. Patients with vitiligo had significantly higher serum homocysteine levels (standardized mean difference [SMD] 0.550, 95% confidence interval [CI] 0.262-0.838; I2 87.3%) and lower vitamin B12 levels (SMD −0.430, 95% CI −0.738 to −0.121; I2 85.3%) than controls. Serum folate levels were not significantly different between the 2 groups (SMD –0.240, 95% CI –0.592 to 0.111; I2 85.5%). A subgroup analysis revealed that these findings correlated with disease activity.
Limitations |
The included studies were heterogeneous. Serum homocysteine levels could be influenced by various factors.
Conclusion |
Patients with vitiligo have higher serum homocysteine levels and lower vitamin B12 levels than individuals without vitiligo.
Le texte complet de cet article est disponible en PDF.Key words : folate, homocysteine, hyperhomocysteinemia, vitamin B12, vitiligo
Abbreviations used : CI, SMD, UVB
Plan
| Dr Tsai and Dr Kuo contributed equally to the study as first authors. |
|
| Funding sources: None. |
|
| Conflicts of interest: None disclosed. |
Vol 80 - N° 3
P. 646 - mars 2019 Retour au numéro
Article précédent
- Comparison of tumor staging systems for cutaneous squamous cell carcinoma in patients with chronic lymphocytic leukemia
- Jacob J. Inda, Brian F. Kabat, Melissa C. Larson, Susan L. Slager, Christian L. Baum
- Prevalence estimates for pemphigoid in the United States: A sex-adjusted and age-adjusted population analysis
- Sara Wertenteil, Amit Garg, Andrew Strunk, Allireza Alloo
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
Déjà abonné à cette revue ?