Association of IL-10 and TGF-beta cytokine gene polymorphisms with autoimmune hepatitis - 07/02/19
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Highlights |
• | The TGF-β +869 C allele was positively and T allele was negatively associated with AIH development. |
• | The TGF-β +869 CC genotype was positively and CT genotype was negatively associated with AIH development. |
• | The TGF-β +915 C allele was positively and G allele was negatively associated with AIH development. |
• | The TGF-β +915 CC genotype was positively and GG genotype was negatively associated with AIH development. |
• | The IL-10 −819 TT genotype was positively associated with AIH development. |
• | The IL-10 –1082 AA genotype was positively and GA genotype was negatively associated with AIH development. |
Summary |
Background and aims |
Autoimmune hepatitis is a chronic immune-mediated liver injury caused by dysregulated immune response to liver antigens. Genetic susceptibility is affected by multiple single nucleotide polymorphisms in immune-related genes. There are few reports on the association of TGF-β and IL-10 genetic variants with autoimmune hepatitis.
Methods |
Allele frequency and genotype status of IL-10 −1082, −819, −592 and TGF-β +869 and +915 polymorphisms were investigated in 57 unrelated patients with autoimmune hepatitis and 140 healthy controls by polymerase chain reaction with sequence-specific primers.
Results |
IL-10 −592 and −819 allele frequencies and genotypes were not associated with autoimmune hepatitis in our population, while IL-10 −1082 genotypes were. IL-10 −1082/−819/−592 “high-producing” haplotype GCC was significantly less frequent in patients. TGF-β +869 “high-producing” allele C and genotype CC were significantly more in autoimmune hepatitis, compared to controls; whereas, TGF-β +915 “low-producing” allele C and genotype CC were significantly more in autoimmune hepatitis compared to control. TGF-β +869/+915 haplotype TG was significantly less frequent in patients while CC haplotype was significantly more frequently observed in patients.
Conclusion |
We identified a significant association between IL-10 −1082/−819 and TGF-β +869/+915 genotypes and haplotypes with autoimmune hepatitis in Iranians.
Le texte complet de cet article est disponible en PDF.Keywords : Liver, Immunogenetic
Plan
Vol 43 - N° 1
P. 45-50 - février 2019 Retour au numéro
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