Imatinib stimulates prostaglandin E2 and attenuates cytokine release via EP4 receptor activation - 07/02/19
Doi : 10.1016/j.jaci.2018.09.030
Thomas Bärnthaler, MD a, Katharina Jandl, PhD b, Heinz Sill, MD c, Barbara Uhl, MD c, Yannick Schreiber, BSc d, Magdalena Grill, PhD a, Dominique Thomas, PhD e, Rudolf Schicho, PhD a, f, Gunther Marsche, PhD a, f, Saša Frank, PhD g, Akos Heinemann, MD a, f, Rufina Schuligoi, PhD a 
a Division of Pharmacology, Otto Loewi Research Center, Medical University of Graz, Graz, Austria
b Ludwig Boltzmann Institute Lung Vascular Research, Graz, Austria
c Division of Hematology, Department of Internal Medicine, Medical University of Graz, Graz, Austria
d Fraunhofer Institute for Molecular Biology and Applied Ecology IME, Project Group TMP, Frankfurt, Germany
e Pharmazentrum Frankfurt/ZAFES Institute of Clinical Pharmacology, Goethe-University Frankfurt, Frankfurt, Germany
f BioTechMed, Graz, Austria
g Division of Molecular Biology and Biochemisty, Gottfried Schatz Research Center, Medical University of Graz, Graz, Austria
| This research was supported by the Austrian Science Fund FWF (grant no. P22521-B18 to A.H.; grant nos. P30144-B26 and KLI521-B31 to R.S.; grant no. P22976-B18 to G.M.; and grant no. P26185-B19 to R.S.), the Jubiläumsfonds of the Austrian National Bank (grant no. 14263 to A.H.), and the LOEWE program from the state of Hesse (Translational Medicine and Pharmacology, TMP, to D.T.). T.B. was funded by the PhD Program DK-MOLIN (FWF – W1241). T.B. is a recipient of a DOC Fellowship of the Austrian Academy of Science and the Start Funding Program of the Medical University of Graz. |
|
| Disclosure of potential conflict of interest: The authors declare that they have no relevant conflicts of interest. |
© 2018
The Authors. Publié par Elsevier Masson SAS. Tous droits réservés.
Vol 143 - N° 2
P. 794 - février 2019 Retour au numéro
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