A cluster of cases of pneumocystis pneumonia identified by shotgun metagenomics approach - 01/02/19
Doi : 10.1016/j.jinf.2018.08.013
Yi Zhang a, 1, Jing-Wen Ai a, 1, Peng Cui a, Wen-Hong Zhang a, ⁎ 
, Hong-Long Wu b, c, Ming-Zhi Ye c
, Hong-Long Wu b, c, Ming-Zhi Ye c a Department of Infectious Disease, Huashan Hospital of Fudan University, Shanghai 200040, China
b Binhai Genomics Institute, Tianjin Translational Genomics Center, BGI-Tianjin, Tianjin, China
c Clinical Laboratory of BGI Health, BGI-genomics, BGI-Shenzhen, Shenzhen 518083, China
⁎Corresponding author.
Highlights |
• | Metagenomics sequencing performed well in diagnosing PCP compared to conventional methods. |
• | Metagenomics exhibited the ability to detect co-infections in PCP patients. |
• | Blood samples metagenomics might suit patients who couldn't tolerate invasive procedures. |
• | Pathogen reads ranking and proportion rate may be the promising cutoff value. |
Keywords : Metagenomics sequencing, Pneumocystis pneumonia, Diagnose
Abbreviations : PCP, BALF, CNS, NAAT, PCR, HE
Plan
© 2018
The British Infection Association. Publié par Elsevier Masson SAS. Tous droits réservés.
Vol 78 - N° 2
P. 158-169 - février 2019 Retour au numéro
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