Interleukin-6 as a diagnostic marker for infection in critically ill patients: A systematic review and meta-analysis - 25/01/19
, Noriyuki Hattori, MD, PhD a, Waka Takahashi, MD, PhD a, Nozomi Takahashi, MD a, Tuerxun Aizimu, MEng b, Masahiro Yoshida, MD, PhD c, Toshio Morizane, MD, PhD d, Shigeto Oda, MD, PhD aAbstract |
Background |
The ability of blood levels of interleukin (IL)-6 to differentiate between infection and non-infection in critically ill patients with suspected infection is unclear. We assessed the diagnostic accuracy of serum IL-6 levels for the diagnosis of infection in critically ill patients.
Methods |
We systematically searched the PubMed, MEDLINE, Cochrane Resister of Controlled Trials, Cochrane Database of Systematic Reviews, CINAHL, and Igaku Chuo Zasshi databases for studies published from 1986 to August 2016 that evaluated the accuracy of IL-6 levels for the diagnosis of infection. We constructed 2 × 2 tables and calculated summary estimates of sensitivity and specificity using a bivariate random-effects model.
Results |
The literature search identified 775 articles, six of which with a total of 527 patients were included according to the predefined criteria. The pooled sensitivity, specificity, and diagnostic odds ratio were 0.73 (95% confidence interval [CI], 0.61–0.82), 0.76 (95% CI, 0.61–0.87), and 2.31 (95% CI, 1.20–3.48), respectively. The area under the curve (AUC) of the summary receiver operator characteristic (SROC) curve was 0.81 (95% CI, 0.78–0.85). In the secondary analysis of two studies with a total of 263 adult critically ill patients with organ dysfunction, the pooled sensitivity, specificity, and diagnostic odds ratio were 0.81 (95% CI, 0.75–0.86), 0.77 (95% CI, 0.67–0.84), and 2.87 (95% CI 2.15–3.60), respectively.
Conclusions |
Blood levels of IL-6 have a moderate diagnostic value and a potential clinical utility to differentiate infection in critically ill patients with suspected infection.
Le texte complet de cet article est disponible en PDF.Keywords : Diagnosis, Biomarker, Critically ill patients, Sepsis, Septic shock, Organ dysfunction
Plan
Vol 37 - N° 2
P. 260-265 - février 2019 Retour au numéro
Article précédent
- Prognostic factors for generalized tetanus in adults: A retrospective study in a Chinese hospital
- Chenliang Sun, Hongsheng Zhao, Yang Lu, Zhiwei Wang, Wanjiang Xue, Shu Lu, Haoliang Shen, Yiping Wang, Qingyun Peng, Lili Huang
- Patient and clinician factors associated with prehospital pain treatment and outcomes: cross sectional study
- Aloysius Niroshan Siriwardena, Zahid Asghar, Bill Lord, Helen Pocock, Viet-Hai Phung, Theresa Foster, Julia Williams, Helen Snooks
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
Déjà abonné à cette revue ?