Prognostic factors for generalized tetanus in adults: A retrospective study in a Chinese hospital - 25/01/19
, Yang Lu, MD a, ⁎ , Zhiwei Wang, MD b, Wanjiang Xue, MD b, Shu Lu, MS a, Haoliang Shen, MS a, Yiping Wang, MS a, Qingyun Peng, MS a, Lili Huang, MS aAbstract |
Background |
We evaluated factors associated with mortality in patients with moderate/severe generalized tetanus.
Methods |
This retrospective study included patients with moderate/severe generalized tetanus admitted to the Affiliated Hospital of Nantong University (China) between January 2005 and January 2017. Clinical data were extracted from medical records. Patients were divided into two groups based on outcome (survival or death). Factors associated with mortality were analyzed using univariate and multivariate logistic regression.
Results |
Seventy-five patients were included (57.3% male; age, 57.9 ± 18.4 years; APACHE II score, 10.6 ± 3.4; severe tetanus, 49.3%; mortality, 25.3%). Multivariate analysis identified severe tetanus (odds ratio [OR], 30.364; 95% confidence interval [CI], 2.459–374.896) and APACHE II score (OR, 1.536; 95%CI, 1.051–2.243) as positively associated with mortality, whereas high-calorie nutrition (OR, 0.027; 95%CI, 0.002–0.359) and dexmedetomidine use (OR, 0.035; 95%CI, 0.003–0.467) were negatively associated with mortality (all P < 0.05).
Conclusion |
Tetanus severity and APACHE II score were associated with mortality in patients with generalized tetanus, whereas high-calorie nutrition and dexmedetomidine use reduced the odds of death. High-calorie nutrition and dexmedetomidine administration may improve prognosis in adult patients with moderate/severe generalized tetanus.
Le texte complet de cet article est disponible en PDF.Keywords : Tetanus, Multivariate analysis, Prognosis, Nutritional support, Dexmedetomidine
Plan
Vol 37 - N° 2
P. 254-259 - février 2019 Retour au numéro
Article précédent
- RETRACTED: Vascular permeability and hemodynamic effects of ulinastatin on organs affected by shock during early burn injury
- Shiyan Li, Weixi Yang, Liangliang Zhou, Dekang Nie, Haizhou Yu
- Interleukin-6 as a diagnostic marker for infection in critically ill patients: A systematic review and meta-analysis
- Shinya Iwase, Taka-aki Nakada, Noriyuki Hattori, Waka Takahashi, Nozomi Takahashi, Tuerxun Aizimu, Masahiro Yoshida, Toshio Morizane, Shigeto Oda
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
Déjà abonné à cette revue ?