The human microbiota in pulmonary tuberculosis: Not so innocent bystanders - 15/01/19

Doi : 10.1016/j.tube.2018.10.010

Samira Tarashi ^a,^b, Sara Ahmadi Badi ^a,^b, Arfa Moshiri ^b,^c,^d, Mahshid Nasehi ^e,^f, Abolfazl Fateh ^a,^b, Farzam Vaziri ^a,^b, Seyed Davar Siadat ^a,^b,^⁎
^a Department of Mycobacteriology and Pulmonary Research, Pasteur Institute of Iran, Tehran, Iran
^b Microbiology Research Center (MRC), Pasteur Institute of Iran, Tehran, Iran
^c Gastroenterology and Liver Disease Research Center, Research Institute for Gastroenterology and Liver Disease, Shahid Beheshti University of Medical Sciences, Tehran, Iran
^d Experimental Therapy Unit, Laboratory of Oncology, G.Gaslini Children's Hospital, Genoa, Italy
^e Center for Communicable Diseases Control, Ministry of Health and Medical Education, Tehran, Iran
^f Department of Epidemiology and Biostatistics, School of Public Health, Iran University of Medical Sciences, Tehran, Iran

^∗Corresponding author. Pasteur Institute of Iran, No. 358, 12th Farvardin Ave, Jomhhoori St, Tehran, Post Code: 1316943551, Iran.Pasteur Institute of IranNo. 358, 12th Farvardin Ave, Jomhhoori StTehranPost Code: 1316943551Iran

Abstract

Mycobacterium tuberculosis (Mtb) infection is a worldwide health concern, which needs robust and efficient control strategies, and the evaluation of human microbiota can be very important in this regard. Dysbiosis of normal microbiota is an important issue in the pathogenesis of Mtb. However, only few studies demonstrated the interaction between Mtb infection and microbiota. The current study aimed at reviewing literature on gut and lung microbiota in Mtb infection. Eleven articles regarding gut and lung microbiota composition in individuals with Mtb infection were selected, and then the importance of gut-lung axis in Mtb infection was evaluated. Also the relationship between microbiota composition and Mtb infection were discussed in terms of treatment, epigenetic field, and biomarkers.

Le texte complet de cet article est disponible en PDF.

Keywords : Mycobacterium tuberculosis, Lung, Gut, Microbiota, Epigenetic

Plan

Introduction

Evidence of gut and lung microbiota in Mtb infection

The importance of microbiota in Mtb infection

The gut-lung axis

The microbiota alteration in Mtb infection

Epigenetic modifications in Mtb infection

The microbiota as biomarker

Future perspective

Export

Vol 113

P. 215-221 - décembre 2018 Retour au numéro

Article précédent

The role of epigenetics, bacterial and host factors in progression of Mycobacterium tuberculosis infection
Musa Marimani, Aijaz Ahmad, Adriano Duse

| Article suivant

Analysis of potential household transmission events of tuberculosis in the city of Belem, Brazil
Emilyn Costa Conceição, Arthur Emil dos Santos Guimarães, Maria Luíza Lopes, Ismari Perini Furlaneto, Yan Corrêa Rodrigues, Marília Lima da Conceição, Wandyra Araújo Barros, Ninarosa Calzavara Cardoso, Abhinav Sharma, Luana Nepomuceno Gondim Costa Lima, Harrison Magdinier Gomes, Rafael Silva Duarte, Cristiane Frota, Liliana K. Rutaihwa, Sebastien Gagneux, Philip Noel Suffys, Karla Valéria Batista Lima

Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.

Déjà abonné à cette revue ?

connectez-vous ou créez un compte

The human microbiota in pulmonary tuberculosis: Not so innocent bystanders - 15/01/19

Abstract

Plan

Export citations

Fichier

Contenu

Accès rapides

Mon compte

Aide & support

Plateformes Elsevier Masson

Déclaration CNIL