A systematic review and meta-analysis of the regional and age-related differences in atopic dermatitis clinical characteristics - 14/01/19
Abstract |
Background |
Previous studies found conflicting results about the commonality of different atopic dermatitis (AD) signs and symptoms.
Objective |
To determine the prevalences of AD characteristics and differences by region and age.
Methods |
A systematic review was performed of all published studies in MEDLINE, EMBASE, SCOPUS, LILACS, Cochrane, China National Knowledge Infrastructure, Taiwan Electronic Periodical Services, and CiNii that analyzed the proportion of AD characteristics. Two reviewers performed a review study titles and/or abstracts and data abstraction.
Results |
In all, 101 studies reported proportion of AD features with sufficient data for meta-analysis. The most prevalent AD features were pruritus, lichenification, and xerosis. There were differences in AD characteristics by study region. Flexural involvement was less commonly reported in India, the Americas, and Iran. Studies from East Asian reported more erythroderma and truncal, extensor, scalp, and auricular involvement. Studies from Southeast Asia reported more exudative eczema, truncal involvement, lichenification, and prurigo nodularis. Studies from Iran reported more head, face, and neck involvement; pityriasis alba; and xerosis. Studies from Africa reported more papular lichenoid lesions, palmar hyperlinearity, ichthyosis, and orbital darkening.
Limitations |
Heterogeneity between studies and limited reporting of certain AD clinical characteristics.
Conclusions |
AD characteristics are heterogeneous and vary by region and age.
Le texte complet de cet article est disponible en PDF.Key words : atopic dermatitis, diagnostic criteria, eczema, epidemiology, meta-analysis, phenotype, prevalence, signs, symptoms, systematic review
Abbreviations used : AD, CI, EA, SEA, UKWP
Plan
| Funding sources: Supported by the Agency for Healthcare Research and Quality (grant K12 HS023011) and the Dermatology Foundation. |
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| Conflicts of interest: None disclosed. |
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| Dr Silverberg had full access to all the data in the study and takes responsibility for the integrity of the data and accuracy of the data analysis. Dr Silverberg and Dr Yew were responsible for the study concept and design. Dr Yew was responsible for acquisition of data. Dr Silverberg, Dr Yew, and Dr Thyssen were responsible for analysis and interpretation of data, as well as for drafting of the article and critical revision of the article for important intellectual content. Dr Yew was responsible for statistical analysis, and Dr Silverberg obtained funding for the study. |
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| Reprints not available from the authors. |
Vol 80 - N° 2
P. 390-401 - février 2019 Retour au numéro
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