Development and Modification of an Outcome Measure to Follow Symptoms of Children with Sinusitis - 12/12/18

Doi : 10.1016/j.jpeds.2018.11.016

Nader Shaikh, MD, MPH ^1,^* , Ellen R. Wald, MD ², Jong-Hyeon Jeong, PhD ³, Marcia Kurs-Lasky, MS ¹, David Nash, MD ⁴, Michael E. Pichichero, MD ⁵, Diana H. Kearney, RN, CCRC ¹, Mary Ann Haralam, CRNP ¹, A'Delbert Bowen, MD ⁶, Lynda L. Flom, MD ⁶, Alejandro Hoberman, MD ¹
¹ Division of General Academic Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, PA
² Department of Pediatrics, University of Wisconsin School of Medicine and Public Health, Madison, WI
³ Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA
⁴ Division of Allergy and Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA
⁵ Pediatric Infectious Diseases, Rochester General Research Institute, Rochester, NY
⁶ Division of Pediatric Radiology, Children's Hospital of Pittsburgh, Pittsburgh, PA

^*Reprint requests: Nader Shaikh, MD, MPH, Children's Hospital of Pittsburgh, General Academic Pediatrics, 4401 Penn Ave, Pittsburgh, PA 15224.Children's Hospital of PittsburghGeneral Academic Pediatrics4401 Penn AvePittsburghPA15224

Sous presse. Épreuves corrigées par l'auteur. Disponible en ligne depuis le Wednesday 12 December 2018

Abstract

Objective

To develop a parent-reported Pediatric Rhinosinusitis Symptom Scale (PRSS) that could be used to monitor symptoms of young children with acute sinusitis in response to therapy.

Study design

We developed an 8-item symptom severity scale and evaluated its internal reliability, construct validity, and responsiveness in children 2-12 years of age with acute sinusitis. Parents of 258 children with acute sinusitis completed the PRSS at the time of diagnosis, as a diary at home, and at the follow-up visit at days 10-12. Based on psychometric results and additional parent feedback, we revised the scale. We evaluated the revised version in 185 children with acute sinusitis.

Results

Correlations between the scale and reference measures on the day of enrollment were in the expected direction and of the expected magnitude. PRSS scores at the time of presentation correlated with radiographic findings (P < .001), functional status (P < .001), and parental assessment of overall symptom severity (P < .001). Responsiveness (standardized response mean) and test–retest reliability of the revised scale were good (2.17 and 0.75, respectively).

Conclusions

We have developed an outcome measure to track the symptoms of acute sinusitis. Data presented here support the use of the PRSS as a measure of change in symptom burden in clinical trials of children with acute sinusitis.

Le texte complet de cet article est disponible en PDF.

Keywords : sinusitis, parent-reported outcome measure, pediatrics, symptoms, outcome measure

Abbreviations : MID, PRSS, SRM