Epidemiologic estimates of hepatitis E virus infection in European countries - 09/12/18
Summary |
Objectives |
Reliable epidemiologic estimates of Hepatitis E Virus (HEV) infection and evidence on factors determining country-differences are sparse. We systematically assessed and extracted research data on three HEV infection markers and identified factors influencing HEV-positivity to generated adjusted EU/EEA country-specific estimates by a meta-analysis.
Methods |
Reports on HEV published 2005–2015 for EU/EEA countries were obtained from PubMed, Embase, Scopus, and Cochrane databases. Utilizing data on anti-HEV IgG, IgM and HEV-RNA we estimated HEV sero-prevalence, recent and acute HEV infections. Respective magnitude of factors influencing HEV-positivity was characterized using deviance. Country-specific estimates were generated by multivariable logistic regression.
Results |
Of 4980 records, 165 covering 18 EU/EEA countries met inclusion criteria. The majority of collected data were published for Germany, France, United Kingdom, The Netherlands, and Spain. Most influential factor for anti-HEV IgG was the assay used (42% of total deviance); IgM and HEV-RNA were predominately determined by studied population (34%, 74%). Adjusted country-specific estimates for anti-HEV IgG ranged from 1.82%–17.06%, IgM 0.14%–6.54%, and HEV-RNA 0.00%–0.10%. No general geographical pattern of HEV-positivity was visible.
Conclusions |
Our analysis revealed a high heterogeneity regarding data availability and HEV-seropositivity across EU/EEA countries. Determinants of HEV-estimates including assay are to be considered when interpreting HEV-epidemiology and its burden.
Le texte complet de cet article est disponible en PDF.Keywords : Hepatitis E Virus, HEV infection marker, HEV positivity, Epidemiology, Europe, EU/EEA, Sero-prevalence
Plan
Vol 77 - N° 6
P. 544-552 - décembre 2018 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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